CD8+ lymphocyte decrease in HIV disease

• Verfasst von: Daniel, Volker [VerfasserIn]
• Verfasst von: Süsal, Caner [VerfasserIn]
• Verfasst von: Weimer, Rolf [VerfasserIn]
• Verfasst von: Zipperle, Silvia [VerfasserIn]
• Verfasst von: Kröpelin, Marianne [VerfasserIn]
• Verfasst von: Zimmermann, Rainer Johannes [VerfasserIn]
• Verfasst von: Huth-Kühne, Angela [VerfasserIn]
• Verfasst von: Gerhard, Ingrid [VerfasserIn]
• Verfasst von: Maier, Heinz [VerfasserIn]
• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Titel: CD8+ lymphocyte decrease in HIV disease
• Titelzusatz: association with anti-CD4+ but not with anti-CD8+ lymphocyte autoantibodies
• Verf.angabe: V. Daniel, C. Süsal, R. Weimer, S. Zipperle, M. Kröpelin, R. Zimmermann, A. Huth-Kühne, I. Gerhard, H. Maier, G. Opelz
• E-Jahr: 1996
• Jahr: February 1996
• Umfang: 6 S.
• Fussnoten: Gesehen am 22.08.2024
• Titel Quelle: Enthalten in: Vox sanguinis
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1956
• Jahr Quelle: 1996
• Band/Heft Quelle: 70(1996), 2, Seite 86-91
• ISSN Quelle: 1423-0410
• DOI: doi:10.1111/j.1423-0410.1996.tb01298.x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1899351140

Abstract

HIV+ patients form autoantibodies against CD4+ and CD8+ lymphocytes. It was shown that anti-CD4+ lymphocyte autoantibodies are associated with the depletion of CD4+ cells. In the present study we analyzed the relationship of anti-CD4+ and anti-CDS+ autoantibodies with the CD8+ lymphocyte decrease commonly observed during HIV disease. IgM and IgG antibodies as well as complement fragments were determined on the surface of CD4+ and CD8+ lymphocytes using double fluorescence flow cytometry. Anti-CD8+ lymphocyte autoantibodies were found more often in HIV+ hemophilia patients (75/105 = 71%) than HIV- hemophilia patients (13/37 = 35%; p<0.0001), patients with pharyngeal carcinoma (20/44 = 45%; p = 0.002), habitual abortions (3/13 = 23%; p = 0.0009) or healthy individuals (93/223 = 42%; p< 0.0001). Anti-CD8+ antibodies, mostly of the IgM type, occurred significantly more frequently than anti-CD4+ antibodies in healthy controls (p< 0.0001), patients with pharyngeal carcinoma (p = 0.0001), or HIV- patients (p = 0.01). In HIV+ patients, however, anti-CD4+ autoantibodies were found more often than anti-CD8+ antibodies (85 vs 71%; p = 0.02). 70 of 104 (67%) HIV+ patients had autoantibodies on both CD4+ and CD8+ lymphocytes and the IgG/IgM/C3d autoantibody pattern was identical in 31 (44%) of the patients. Interestingly, peripheral blood CD8+ cell counts were significantly associated with anti-CD4+ (p = 0.01) but not with anti-CD8+ lymphocyte autoantibodies. It is hypothesized that the inhibition and depletion of CD4+ cells by anti-CD4+ autoantibodies is associated with a loss of regulatory functions that leads to a depletion of antiviral cytotoxic CD8+ lymphocytes.