Impaired in-vitro lymphocyte responses in patients with elevated pentachlorophenol (PCP) blood levels

• Verfasst von: Daniel, Volker [VerfasserIn]
• Verfasst von: Huber, Wolfgang [VerfasserIn]
• Verfasst von: Bauer, Klausdieter [VerfasserIn]
• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Titel: Impaired in-vitro lymphocyte responses in patients with elevated pentachlorophenol (PCP) blood levels
• Verf.angabe: Volker Daniel, Wolfgang Huber, Klausdieter Bauer, Gerhard Opelz
• Jahr: 1995
• Umfang: 6 S.
• Fussnoten: Elektronische Reproduktion der Druck-Ausgabe 3. August 2010 ; Gesehen am 22.08.2024
• Titel Quelle: Enthalten in: Archives of environmental health
• Ort Quelle: Washington, DC : Heldref Publications, 1975
• Jahr Quelle: 1995
• Band/Heft Quelle: 50(1995), 4, Seite 287-292
• ISSN Quelle: 2331-4303
• DOI: doi:10.1080/00039896.1995.9935956
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1899357653

Abstract

Immune parameters were examined in 188 patients who were exposed for more than 6 mo to pentachlorophenol-containing pesticides. Blood levels of pentachlorophenol, lymphocyte subpopulations, in-vitro responses to mitogenic and allogeneic stimulation, plasma neopterin levels, and plasma cytokine and cytokine receptor levels were determined. Impaired in-vitro lymphocyte stimulation responses were impaired in 65% of the patients. The likelihood of impaired lymphocyte stimulation increased significantly with levels of pentachlorophenol that exceeded 10 μl/l (p < .05). Patients who had high blood levels of pentachlorophenol and abnormal lymphocyte stimulation also had increased proportions of blood monocytes in blood (p < .05), as well as increased IL-8 serum levels (p < .02). Eleven patients who had abnormal mitogen stimulation experienced decreased CD4/CD8 ratios of < 1.0; 5 of these patients had decreased CD4+ lymphocyte counts of < 500/μl, and 3 patients had increased plasma neopterin of < 15 nmol/l. These results indicate that increased levels of pentachlorophenol in blood can lead to severe T lymphocyte dysfunction.