Classification of Vitamin D status based on Vitamin D metabolism

• Verfasst von: Zelzer, Sieglinde [VerfasserIn]
• Verfasst von: Meinitzer, Andreas [VerfasserIn]
• Verfasst von: Enko, Dietmar [VerfasserIn]
• Verfasst von: Keppel, Martin H. [VerfasserIn]
• Verfasst von: Herrmann, Markus [VerfasserIn]
• Verfasst von: Theiler-Schwetz, Verena [VerfasserIn]
• Verfasst von: Trummer, Christian [VerfasserIn]
• Verfasst von: Schmitt, Lisa [VerfasserIn]
• Verfasst von: Tomaschitz, Andreas [VerfasserIn]
• Verfasst von: Sadoghi, Patrick [VerfasserIn]
• Verfasst von: Dierkes, Jutta [VerfasserIn]
• Verfasst von: Pludowski, Pawel [VerfasserIn]
• Verfasst von: Zittermann, Armin [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Verfasst von: Pilz, Stefan [VerfasserIn]
• Titel: Classification of Vitamin D status based on Vitamin D metabolism
• Titelzusatz: a randomized controlled trial in hypertensive patients
• Verf.angabe: Sieglinde Zelzer, Andreas Meinitzer, Dietmar Enko, Martin H. Keppel, Markus Herrmann, Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Andreas Tomaschitz, Patrick Sadoghi, Jutta Dierkes, Pawel Pludowski, Armin Zittermann, Winfried März and Stefan Pilz
• E-Jahr: 2024
• Jahr: 14 March 2024
• Umfang: 12 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 22.08.2024
• Titel Quelle: Enthalten in: Nutrients
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2024
• Band/Heft Quelle: 16(2024), 6, Artikel-ID 839, Seite 1-12
• ISSN Quelle: 2072-6643
• DOI: doi:10.3390/nu16060839
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 24
• Sach-SW: 25-dihydroxyvitamin D
• Sach-SW: classification
• Sach-SW: deficiency
• Sach-SW: RCT
• Sach-SW: supplementation
• Sach-SW: vitamin D
• Sach-SW: vitamin D metabolite ratio
• K10plus-PPN: 1899358935

Abstract

Circulating 25-hydroxyvitamin D (25(OH)D) is the generally accepted indicator of vitamin D status. Since hydroxylation of 25(OH)D to 24-25-dihydroxyvitamin D (24,25(OH)2D) is the first step of its catabolism, it has been suggested that a low 24,25(OH)D level and a low vitamin D metabolite ratio (VMR), i.e., 24,25(OH)2D divided by 25(OH)D, may indicate high vitamin D requirements and provide additional diagnostic information beyond serum 25(OH)D. We, therefore, evaluated whether the classification of “functional vitamin D deficiency”, i.e., 25(OH)D below 50 nmol/L, 24,25(OH)2D below 3 nmol/L and a VMR of less than 4%, identifies individuals who benefit from vitamin D supplementation. In participants of the Styrian Vitamin D Hypertension trial, a randomized controlled trial (RCT) in 200 hypertensive patients with serum 25(OH)D below 75 nmol/L, who received either 2.800 international units of vitamin D per day or placebo over 8 weeks, 51 participants had functional vitamin D deficiency. In these individuals, there was no treatment effect of vitamin D supplementation on various parameters of bone metabolism and cardiovascular risk except for a significant effect on parathyroid hormone (PTH) and expected changes in vitamin D metabolites. In conclusion, a low vitamin D metabolite profile did not identify individuals who significantly benefit from vitamin D supplementation with regard to bone markers and cardiovascular risk factors. The clinical significance of functional vitamin D deficiency requires further evaluation in large vitamin D RCTs.