Decreased alloreactivity after vaccination against hepatitis B

• Verfasst von: Ruder, Hans [VerfasserIn]
• Verfasst von: Kerling, Frank [VerfasserIn]
• Verfasst von: Daniel, Volker [VerfasserIn]
• Verfasst von: Korn, Klaus [VerfasserIn]
• Verfasst von: Waßmuth, Ralf [VerfasserIn]
• Titel: Decreased alloreactivity after vaccination against hepatitis B
• Verf.angabe: Hans Ruder, Frank Kerling, Volker Daniel, Klaus Korn, Ralf Wassmuth
• E-Jahr: 1995
• Jahr: May 15, 1995
• Umfang: 4 S.
• Fussnoten: Gesehen am 22.08.2024
• Titel Quelle: Enthalten in: Transplantation
• Ort Quelle: Hagerstown, Md. : Lippincott Williams & Wilkins, 1963
• Jahr Quelle: 1995
• Band/Heft Quelle: 59(1995), 9, Seite 1339-1342
• ISSN Quelle: 1534-6080
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1899366245

Abstract

The beneficial effect of blood transfusions on renal allografts disappeared at about the same time when hepatitis B vaccination was introduced in dialysis patients. To determine possible immunosuppressive effects of hepatitis B vaccination, we studied alloreactivity during the course of immunization. Fourteen healthy subjects without serological evidence of hepatitis B were routinely immunized against hepatitis B surface antigen. Plasma and mononuclear cells were isolated and frozen before immunization and after vaccination, respectively. Mean alloreactivity measured by [3H]thymidine uptake decreased from 64,772 cpm before immunization to 40,213 cpm after the third immunization. In crossover experiments, cellular modulation and plasma-dependent modulation of alloreactivity were observed. The immunosuppressive effect of plasma taken 4 weeks after the third vaccination correlated (r=0.9) highly significantly (P<0.005) with the anti-hepatitis B surface antigen antibody titer. Taken together, our data strongly suggest that hepatitis B vaccination is capable of reducing allogenic reactivity.