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| Verfasst von: | Winkler, Ivana [VerfasserIn]  |
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| | Tolkachov, Alexander [VerfasserIn] |
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| | Lammers, Fritjof Paul [VerfasserIn] |
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| | Lacour, Perrine [VerfasserIn] |
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| | Daugėlaitė, Klaudija [VerfasserIn] |
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| | Schneider, Nina [VerfasserIn] |
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| | Koch, Marie-Luise [VerfasserIn] |
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| | Panten, Jasper [VerfasserIn] |
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| | Grünschläger, Florian [VerfasserIn] |
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| | Poth, Tanja [VerfasserIn] |
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| | Ávila, Bianca Machado de [VerfasserIn] |
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| | Schneider, Augusto [VerfasserIn] |
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| | Haas, Simon [VerfasserIn] |
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| | Odom, Duncan T. [VerfasserIn] |
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| | Gonçalves, Ângela [VerfasserIn] |
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| Titel: | The cycling and aging mouse female reproductive tract at single-cell resolution |
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| Verf.angabe: | Ivana Winkler, Alexander Tolkachov, Fritjof Lammers, Perrine Lacour, Klaudija Daugelaite, Nina Schneider, Marie-Luise Koch, Jasper Panten, Florian Grünschläger, Tanja Poth, Bianca Machado de Ávila, Augusto Schneider, Simon Haas, Duncan T. Odom, and Ângela Gonçalves |
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| E-Jahr: | 2024 |
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| Jahr: | 15 February 2024 |
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| Umfang: | 44 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 6. Februar 2024, Artikelversion: 15. Februar 2024 ; Gesehen am 22.08.2024 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 187(2024), 4 vom: Feb., Seite 981-998.e25 |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | The female reproductive tract (FRT) undergoes extensive remodeling during reproductive cycling. This recurrent remodeling and how it shapes organ-specific aging remains poorly explored. Using single-cell and spatial transcriptomics, we systematically characterized morphological and gene expression changes occurring in ovary, oviduct, uterus, cervix, and vagina at each phase of the mouse estrous cycle, during decidualization, and into aging. These analyses reveal that fibroblasts play central—and highly organ-specific—roles in FRT remodeling by orchestrating extracellular matrix (ECM) reorganization and inflammation. Our results suggest a model wherein recurrent FRT remodeling over reproductive lifespan drives the gradual, age-related development of fibrosis and chronic inflammation. This hypothesis was directly tested using chemical ablation of cycling, which reduced fibrotic accumulation during aging. Our atlas provides extensive detail into how estrus, pregnancy, and aging shape the organs of the female reproductive tract and reveals the unexpected cost of the recurrent remodeling required for reproduction. |
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| DOI: | doi:10.1016/j.cell.2024.01.021 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.cell.2024.01.021 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0092867424000588 |
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| | DOI: https://doi.org/10.1016/j.cell.2024.01.021 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | aging |
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| | cervix |
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| | fibrosis |
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| | inflammation |
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| | ovary |
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| | oviduct |
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| | single cell |
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| | spatial |
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| | uterus |
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| | vagina |
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| K10plus-PPN: | 1899375783 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ cycling and aging mouse female reproductive tract at single-cell resolution / Winkler, Ivana [VerfasserIn]; 15 February 2024 (Online-Ressource)
