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| Verfasst von: | Groß, Rüdiger Martin [VerfasserIn]  |
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| | Reßin, Hanna [VerfasserIn] |
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| | von Maltitz, Pascal [VerfasserIn] |
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| | Albers, Dan [VerfasserIn] |
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| | Schneider, Laura [VerfasserIn] |
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| | Bley, Hanna [VerfasserIn] |
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| | Hoffmann, Markus [VerfasserIn] |
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| | Cortese, Mirko [VerfasserIn] |
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| | Gupta, Dhanu [VerfasserIn] |
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| | Deniz, Miriam [VerfasserIn] |
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| | Choi, Jae-Yeon [VerfasserIn] |
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| | Jansen, Jenny [VerfasserIn] |
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| | Preußer, Christian [VerfasserIn] |
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| | Seehafer, Kai [VerfasserIn] |
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| | Pöhlmann, Stefan [VerfasserIn] |
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| | Voelker, Dennis R. [VerfasserIn] |
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| | Laqmani-Goffinet, Christine [VerfasserIn] |
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| | Pogge-von Strandmann, Elke [VerfasserIn] |
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| | Bunz, Uwe H. F. [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | El Andaloussi, Samir [VerfasserIn] |
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| | Sparrer, Konstantin MJ [VerfasserIn] |
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| | Herker, Eva [VerfasserIn] |
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| | Becker, Stephan [VerfasserIn] |
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| | Kirchhoff, Frank [VerfasserIn] |
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| | Münch, Jan [VerfasserIn] |
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| | Müller, Janis A. [VerfasserIn] |
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| Titel: | Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens |
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| Verf.angabe: | Rüdiger Groß, Hanna Reßin, Pascal von Maltitz, Dan Albers, Laura Schneider, Hanna Bley, Markus Hoffmann, Mirko Cortese, Dhanu Gupta, Miriam Deniz, Jae-Yeon Choi, Jenny Jansen, Christian Preußer, Kai Seehafer, Stefan Pöhlmann, Dennis R. Voelker, Christine Goffinet, Elke Pogge-von Strandmann, Uwe Bunz, Ralf Bartenschlager, Samir El Andaloussi, Konstantin M. J. Sparrer, Eva Herker, Stephan Becker, Frank Kirchhoff, Jan Münch & Janis A. Müller |
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| E-Jahr: | 2024 |
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| Jahr: | 25 March 2024 |
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| Umfang: | 27 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 23.08.2024 |
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| Titel Quelle: | Enthalten in: Nature microbiology |
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| Ort Quelle: | London : Nature Publishing Group, 2016 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 9(2024), 4, Seite 905-921 |
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| ISSN Quelle: | 2058-5276 |
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| Abstract: | Some viruses are rarely transmitted orally or sexually despite their presence in saliva, breast milk, or semen. We previously identified that extracellular vesicles (EVs) in semen and saliva inhibit Zika virus infection. However, the antiviral spectrum and underlying mechanism remained unclear. Here we applied lipidomics and flow cytometry to show that these EVs expose phosphatidylserine (PS). By blocking PS receptors, targeted by Zika virus in the process of apoptotic mimicry, they interfere with viral attachment and entry. Consequently, physiological concentrations of EVs applied in vitro efficiently inhibited infection by apoptotic mimicry dengue, West Nile, Chikungunya, Ebola and vesicular stomatitis viruses, but not severe acute respiratory syndrome coronavirus 2, human immunodeficiency virus 1, hepatitis C virus and herpesviruses that use other entry receptors. Our results identify the role of PS-rich EVs in body fluids in innate defence against infection via viral apoptotic mimicries, explaining why these viruses are primarily transmitted via PS-EV-deficient blood or blood-ingesting arthropods rather than direct human-to-human contact. |
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| DOI: | doi:10.1038/s41564-024-01637-6 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41564-024-01637-6 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41564-024-01637-6 |
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| | DOI: https://doi.org/10.1038/s41564-024-01637-6 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Viral infection |
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| | Viral transmission |
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| | Virus-host interactions |
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| K10plus-PPN: | 1899417826 |
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| Verknüpfungen: | → Zeitschrift |
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Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens / Groß, Rüdiger Martin [VerfasserIn]; 25 March 2024 (Online-Ressource)
