| |  Online-Ressource |
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| Verfasst von: | Tabouret, Emeline [VerfasserIn]  |
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| | Furtner, Julia [VerfasserIn] |
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| | Graillon, Thomas [VerfasserIn] |
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| | Silvani, Antonio [VerfasserIn] |
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| | Le Rhun, Emilie [VerfasserIn] |
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| | Soffietti, Riccardo [VerfasserIn] |
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| | Lombardi, Giuseppe [VerfasserIn] |
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| | Sepúlveda-Sánchez, Juan Manuel [VerfasserIn] |
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| | Brandal, Petter [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Golfinopoulos, Vassilis [VerfasserIn] |
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| | Gorlia, Thierry [VerfasserIn] |
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| | Weller, Michael [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Preusser, Matthias [VerfasserIn] |
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| Titel: | 3D volume growth rate evaluation in the EORTC-BTG-1320 clinical trial for recurrent WHO grade 2 and 3 meningiomas |
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| Verf.angabe: | Emeline Tabouret, Julia Furtner, Thomas Graillon, Antonio Silvani, Emilie Le Rhun, Riccardo Soffietti, Giuseppe Lombardi, Juan Manuel Sepúlveda-Sánchez, Petter Brandal, Martin Bendszus, Vassilis Golfinopoulos, Thierry Gorlia, Michael Weller, Felix Sahm, Wolfgang Wick, and Matthias Preusser |
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| E-Jahr: | 2024 |
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| Jahr: | July 2024 |
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| Umfang: | 8 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 07. März 2024 ; Gesehen am 23.08.2024 |
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| Titel Quelle: | Enthalten in: Neuro-Oncology |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1999 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 26(2024), 7 vom: Juli, Seite 1302-1309 |
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| ISSN Quelle: | 1523-5866 |
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| Abstract: | Background: We previously reported that tumor 3D volume growth rate (3DVGR) classification could help in the assessment of drug activity in patients with meningioma using 3 main classes and a total of 5 subclasses: class 1: decrease; 2: stabilization or severe slowdown; 3: progression. The EORTC-BTG-1320 clinical trial was a randomized phase II trial evaluating the efficacy of trabectedin for recurrent WHO 2 or 3 meningioma. Our objective was to evaluate the discriminative value of 3DVGR classification in the EORTC-BTG-1320. Methods: All patients with at least 1 available MRI before trial inclusion were included. 3D volume was evaluated on consecutive MRI until progression. 2D imaging response was centrally assessed by MRI modified Macdonald criteria. Clinical benefit was defined as neurological or functional status improvement or steroid decrease or discontinuation. Results: Sixteen patients with a median age of 58.5 years were included. Best 3DVGR classes were: 1, 2A, 3A, and 3B in 2 (16.7%), 4 (33.3%), 2 (16.7%), and 4 (33.3%) patients, respectively. All patients with progression-free survival longer than 6 months had best 3DVGR class 1 or 2. 3DVGR classes 1 and 2 (combined) had a median overall survival of 34.7 months versus 7.2 months for class 3 (P = .061). All class 1 patients (2/2), 75% of class 2 patients (3/4), and only 10% of class 3 patients (1/10) had clinical benefit. Conclusions: Tumor 3DVGR classification may be helpful to identify early signals of treatment activity in meningioma clinical trials. |
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| DOI: | doi:10.1093/neuonc/noae037 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/neuonc/noae037 |
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| | DOI: https://doi.org/10.1093/neuonc/noae037 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 189944002X |
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| Verknüpfungen: | → Zeitschrift |
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3D volume growth rate evaluation in the EORTC-BTG-1320 clinical trial for recurrent WHO grade 2 and 3 meningiomas / Tabouret, Emeline [VerfasserIn]; July 2024 (Online-Ressource)
