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Status: Bibliographieeintrag

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Verfasst von:Penack, Olaf [VerfasserIn]   i
 Abouqateb, Mouad [VerfasserIn]   i
 Peczynski, Christophe [VerfasserIn]   i
 Boreland, William [VerfasserIn]   i
 Gülbas, Zafer [VerfasserIn]   i
 Gedde-Dahl, Tobias [VerfasserIn]   i
 Castilla-Llorente, Cristina [VerfasserIn]   i
 Kröger, Nicolaus [VerfasserIn]   i
 Eder, Mathias [VerfasserIn]   i
 Rambaldi, Alessandro [VerfasserIn]   i
 Bonifazi, Francesca [VerfasserIn]   i
 Blau, Igor Wolfgang [VerfasserIn]   i
 Stelljes, Matthias [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
 Moiseev, Ivan [VerfasserIn]   i
 Schoemans, Hélène [VerfasserIn]   i
 Koenecke, Christian [VerfasserIn]   i
 Peric, Zinaida [VerfasserIn]   i
Titel:PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation
Verf.angabe:Olaf Penack, Mouad Abouqateb, Christophe Peczynski, William Boreland, Zafer Gülbas, Tobias Gedde-Dahl, Cristina Castilla-Llorente, Nicolaus Kröger, Mathias Eder, Alessandro Rambaldi, Francesca Bonifazi, Igor Wolfgang Blau, Matthias Stelljes, Peter Dreger, Ivan Moiseev, Hélène Schoemans, Christian Koenecke and Zinaida Peric
E-Jahr:2024
Jahr:15 March 2024
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 23.08.2024
Titel Quelle:Enthalten in: Blood cancer journal
Ort Quelle:[London] : Springer Nature, 2011
Jahr Quelle:2024
Band/Heft Quelle:14(2024), Artikel-ID 45, Seite 1-8
ISSN Quelle:2044-5385
Abstract:There is an increased risk of GVHD and of non-relapse mortality (NRM) after allogeneic stem cell transplantations (alloSCT) when mismatched unrelated donors (MMUD) are used. In Europe, it is standard practice to use rabbit anti-thymocyte globulin (rATG) to reduce the high NRM and GVHD risks after MMUD alloSCT. As an alternative to rATG, post-transplantation Cyclophosphamide (PTCy) is in increasing clinical use. It is currently impossible to give general recommendations regarding preference for one method over another since comparative evidence from larger data sets is lacking. To improve the evidence base, we analyzed the outcome of rATG vs. PTCy prophylaxis in adult patients with hematologic malignancies undergoing first peripheral blood alloSCT from MMUD (9/10 antigen match) between Jan 2018 and June 2021 in the database of the European Society for Blood and Marrow Transplantation (EBMT). We performed multivariate analyses using the Cox proportional-hazards regression model. We included 2123 patients in the final analyses (PTCy, n = 583; rATG, n = 1540). p values and hazard ratios (HR) presented here are multivariate outcomes. Two years after alloSCT we found a lower NRM in the PTCy group of 18% vs. 24.9% in the rATG group; p = 0.028, HR 0.74. Overall survival in the PTCy cohort was higher with 65.7% vs. 55.7% in the rATG cohort; p < 0.001, HR 0.77. Progression-free survival was also better in the PTCy patients with 59.1% vs. 48.8% when using rATG; p = 0.001, 0.78. The incidences of chronic GVHD and acute GVHD were not significantly different between the groups. We found significantly lower NRM as well as higher survival in recipients of peripheral blood alloSCTs from MMUD receiving PTCy as compared to rATG. The results of the current analysis suggest an added value of PTCy as GVHD prophylaxis in MMUD alloSCT.
DOI:doi:10.1038/s41408-024-01032-8
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1038/s41408-024-01032-8
 kostenfrei: Volltext: https://www.nature.com/articles/s41408-024-01032-8
 DOI: https://doi.org/10.1038/s41408-024-01032-8
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Graft-versus-host disease
 Stem-cell research
 Translational research
K10plus-PPN:1899456902
Verknüpfungen:→ Zeitschrift

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