| |  Online-Ressource |
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| Verfasst von: | Onabajo, Olusegun O. [VerfasserIn]  |
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| | Banday, A. Rouf [VerfasserIn] |
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| | Stanifer, Megan [VerfasserIn] |
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| | Yan, Wusheng [VerfasserIn] |
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| | Obajemu, Adeola [VerfasserIn] |
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| | Santer, Deanna M. [VerfasserIn] |
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| | Florez-Vargas, Oscar [VerfasserIn] |
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| | Piontkivska, Helen [VerfasserIn] |
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| | Vargas, Joselin M. [VerfasserIn] |
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| | Ring, Timothy J. [VerfasserIn] |
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| | Kee, Carmon [VerfasserIn] |
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| | Doldan, Patricio [VerfasserIn] |
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| | Tyrrell, D. Lorne [VerfasserIn] |
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| | Mendoza, Juan L. [VerfasserIn] |
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| | Boulant, Steeve [VerfasserIn] |
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| | Prokunina-Olsson, Ludmila [VerfasserIn] |
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| Titel: | Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor |
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| Verf.angabe: | Olusegun O. Onabajo, A. Rouf Banday, Megan L. Stanifer, Wusheng Yan, Adeola Obajemu, Deanna M. Santer, Oscar Florez-Vargas, Helen Piontkivska, Joselin M. Vargas, Timothy J. Ring, Carmon Kee, Patricio Doldan, D. Lorne Tyrrell, Juan L. Mendoza, Steeve Boulant and Ludmila Prokunina-Olsson |
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| Jahr: | 2020 |
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| Umfang: | 31 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 26.08.2024 |
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| Titel Quelle: | Enthalten in: Nature genetics |
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| Ort Quelle: | London : Macmillan Publishers Limited, part of Springer Nature, 1992 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 52(2020), 12 vom: Dez., Seite 1283-1293, [1]-[17], 1-4 |
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| ISSN Quelle: | 1546-1718 |
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| Abstract: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, utilizes angiotensin-converting enzyme 2 (ACE2) for entry into target cells. ACE2 has been proposed as an interferon-stimulated gene (ISG). Thus, interferon-induced variability in ACE2 expression levels could be important for susceptibility to COVID-19 or its outcomes. Here, we report the discovery of a novel, transcriptionally independent truncated isoform of ACE2, which we designate as deltaACE2 (dACE2). We demonstrate that dACE2, but not ACE2, is an ISG. In The Cancer Genome Atlas, the expression of dACE2 was enriched in squamous tumors of the respiratory, gastrointestinal and urogenital tracts. In vitro, dACE2, which lacks 356 amino-terminal amino acids, was non-functional in binding the SARS-CoV-2 spike protein and as a carboxypeptidase. Our results suggest that the ISG-type induction of dACE2 in IFN-high conditions created by treatments, an inflammatory tumor microenvironment or viral co-infections is unlikely to increase the cellular entry of SARS-CoV-2 and promote infection. |
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| DOI: | doi:10.1038/s41588-020-00731-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41588-020-00731-9 |
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| | Volltext: https://www.nature.com/articles/s41588-020-00731-9 |
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| | DOI: https://doi.org/10.1038/s41588-020-00731-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Computational biology and bioinformatics |
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| | Diseases |
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| | Genetics research |
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| | Medical research |
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| | Molecular biology |
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| K10plus-PPN: | 1899550356 |
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| Verknüpfungen: | → Zeitschrift |
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Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor / Onabajo, Olusegun O. [VerfasserIn]; 2020 (Online-Ressource)
