| |  Online-Ressource |
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| Verfasst von: | Althammer, Ferdinand [VerfasserIn]  |
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| | Wimmer, Moritz Claudius [VerfasserIn] |
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| | Krabichler, Quirin [VerfasserIn] |
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| | Schimmer, Stephanie [VerfasserIn] |
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| | Schimmer, Jonas [VerfasserIn] |
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| | Fröhlich, Henning [VerfasserIn] |
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| | Dötsch, Laura [VerfasserIn] |
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| | Gruber, Tim [VerfasserIn] |
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| | Wunsch, Selina [VerfasserIn] |
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| | Schubert, Tim [VerfasserIn] |
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| | Kirchner, Matthew K. [VerfasserIn] |
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| | Stern, Javier E. [VerfasserIn] |
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| | Charlet, Alexandre [VerfasserIn] |
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| | Grinevich, Valéry [VerfasserIn] |
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| | Schaaf, Christian P. [VerfasserIn] |
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| Titel: | Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome |
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| Verf.angabe: | Ferdinand Althammer, Moritz Claudius Wimmer, Quirin Krabichler, Stephanie Küppers, Jonas Schimmer, Henning Fröhlich, Laura Dötsch, Tim Gruber, Selina Wunsch, Tim Schubert, Matthew K. Kirchner, Javier E. Stern, Alexandre Charlet, Valery Grinevich, Christian P. Schaaf |
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| E-Jahr: | 2022 |
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| Jahr: | December 2022 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Erstmals online veröffentlicht: 14. November 2022 ; Gesehen am 27.08.2024 |
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| Titel Quelle: | Enthalten in: Journal of neuroendocrinology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1989 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 34(2022), 12 vom: Dez., Artikel-ID e13217, Seite 1-13 |
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| ISSN Quelle: | 1365-2826 |
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| Abstract: | Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by hyperphagia, obesity, developmental delay and intellectual disability. Studies suggest dysfunctional signaling of the neuropeptide oxytocin as one of the key mechanisms in PWS, and administration of oxytocin via intranasal or systemic routes yielded promising results in both humans and mouse models. However, a detailed assessment of the oxytocin system in mouse models of PWS such as the Magel2-deficient Magel2tm1.Stw mouse, is lacking. In the present study, we performed an automated counting of oxytocin cells in the entire paraventricular nucleus of the hypothalamus of Magel2tm1.Stw and wild-type control mice and found a significant reduction in the caudal part, which represents the parvocellular subdivision. In addition, based on the recent discovery that some astrocytes express the oxytocin receptor (OTR), we performed detailed analysis of astrocyte numbers and morphology in various brain regions, and assessed expression levels of the astrocyte marker glial fibrillary acidic protein, which was significantly decreased in the hypothalamus, but not other brain regions in Magel2tm1.Stw mice. Finally, we analyzed the number of OTR-expressing astrocytes in various brain regions and found a significant reduction in the nucleus accumbens of Magel2tm1.Stw mice, as well as a sex-specific difference in the lateral septum. This study suggests a role for caudal paraventricular nucleus oxytocin neurons as well as OTR-expressing astrocytes in a mouse model of PWS, provides novel information about sex-specific expression of astrocytic OTRs, and presents several new brain regions containing OTR-expressing astrocytes in the mouse brain. |
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| DOI: | doi:10.1111/jne.13217 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1111/jne.13217 |
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| | kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/jne.13217 |
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| | DOI: https://doi.org/10.1111/jne.13217 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | astrocytes |
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| | oxytocin |
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| | Prader-Willi syndrome |
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| | Schaaf-Yang syndrome |
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| K10plus-PPN: | 1899587322 |
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| Verknüpfungen: | → Zeitschrift |
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Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome / Althammer, Ferdinand [VerfasserIn]; December 2022 (Online-Ressource)
