The gut microbiome modulates associations between adherence to a Mediterranean-style diet, abdominal adiposity, and C-reactive protein in population-level analysis

• Verfasst von: Jennings, Amy [VerfasserIn]
• Verfasst von: Kühn, Tilman [VerfasserIn]
• Verfasst von: Bondonno, Nicola P. [VerfasserIn]
• Verfasst von: Waniek, Sabina [VerfasserIn]
• Verfasst von: Bang, Corinna [VerfasserIn]
• Verfasst von: Franke, Andre [VerfasserIn]
• Verfasst von: Kassubek, Jan [VerfasserIn]
• Verfasst von: Müller, Hans-Peter [VerfasserIn]
• Verfasst von: Both, Marcus [VerfasserIn]
• Verfasst von: Weber, Katharina S. [VerfasserIn]
• Verfasst von: Lieb, Wolfgang [VerfasserIn]
• Verfasst von: Cassidy, Aedín [VerfasserIn]
• Titel: The gut microbiome modulates associations between adherence to a Mediterranean-style diet, abdominal adiposity, and C-reactive protein in population-level analysis
• Verf.angabe: Amy Jennings, Tilman Kühn, Nicola P. Bondonno, Sabina Waniek, Corinna Bang, Andre Franke, Jan Kassubek, Hans-Peter Müller, Marcus Both, Katharina S. Weber, Wolfgang Lieb, Aedín Cassidy
• Jahr: 2024
• Umfang: 9 S.
• Illustrationen: Diagramme
• Fussnoten: Online verfügbar: 4 November 2023 ; Gesehen am 30.08.2024
• Titel Quelle: Enthalten in: The American journal of clinical nutrition
• Ort Quelle: Amsterdam : Elsevier, 1952
• Jahr Quelle: 2024
• Band/Heft Quelle: 119(2024), 1 vom: Jan., Seite 136-144
• ISSN Quelle: 1938-3207
• ISSN Quelle: 1938-3215
• DOI: doi:10.1016/j.ajcnut.2023.11.001
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: adipose tissue
• Sach-SW: Adiposity
• Sach-SW: C-Reactive Protein
• Sach-SW: diet
• Sach-SW: Diet, Mediterranean
• Sach-SW: Female
• Sach-SW: Gastrointestinal Microbiome
• Sach-SW: gut microbiome
• Sach-SW: Humans
• Sach-SW: inflammation
• Sach-SW: Inflammation
• Sach-SW: Intra-Abdominal Fat
• Sach-SW: Male
• Sach-SW: Obesity, Abdominal
• Sach-SW: RNA, Ribosomal, 16S
• K10plus-PPN: 1900692171

Abstract

BACKGROUND: Adherence to a Mediterranean-style dietary pattern is likely to have variable effects on body composition, but the impact of gut microbiome on this relationship is unknown. - OBJECTIVES: To examine the potential mediating effect of the gut microbiome on the associations between Alternate Mediterranean Diet (aMed) scores, abdominal adiposity, and inflammation in population-level analysis. - DESIGN: In a community-based sample aged 25 to 83 y (n = 620; 41% female) from Northern Germany, we assessed the role of the gut microbiome, sequenced from 16S rRNA genes, on the associations between aMed scores, estimated using validated food-frequency questionnaires, magnetic resonance imaging-determined visceral (VAT) and subcutaneous (SAT) adipose tissue and C-reactive protein (CRP). - RESULTS: Higher aMed scores were associated with lower SAT (-0.86 L (95% CI: -1.56, -0.17), P = 0.01), VAT (-0.65 L (95% CI: -1.03,-0.27), P = 0.01) and CRP concentrations (-0.35 mg/L; β: -20.1% (95% CI: 35.5, -1.09), P = 0.04) in the highest versus lowest tertile after multivariate adjustment. Of the taxa significantly associated with aMed scores, higher abundance of Porphyromonadaceae mediated 11.6%, 9.3%, and 8.7% of the associations with lower SAT, VAT, and CRP, respectively. Conversely, a lower abundance of Peptostreptococcaceae mediated 13.1% and 18.2% of the association with SAT and CRP levels. Of the individual components of the aMed score, moderate alcohol intake was associated with lower VAT (-0.2 (95% CI: -0.4, -0.1), P =0.01) with a higher abundance of Oxalobacteraceae and lower abundance of Burkholderiaceae explaining 8.3% and 9.6% of this association, respectively. - CONCLUSION: These novel data suggest that abundance of specific taxa in the Porphyromonadaceae and Peptostreptococcaceae families may contribute to the association between aMed scores, lower abdominal adipose tissue, and inflammation.