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Status: Bibliographieeintrag

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Verfasst von:Hörner, Sarah J. [VerfasserIn]   i
 Couturier, Nathalie [VerfasserIn]   i
 Gueiber, Daniele Caroline [VerfasserIn]   i
 Hafner, Mathias [VerfasserIn]   i
 Rudolf, Rüdiger [VerfasserIn]   i
Titel:Development and in vitro differentiation of Schwann cells
Verf.angabe:Sarah Janice Hörner, Nathalie Couturier, Daniele Caroline Gueiber, Mathias Hafner and Rüdiger Rudolf
E-Jahr:2022
Jahr:24 November 2022
Umfang:43 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 02.09.2024
Titel Quelle:Enthalten in: Cells
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2022
Band/Heft Quelle:11(2022), 23, Artikel-ID 3753, Seite 1-43
ISSN Quelle:2073-4409
Abstract:Schwann cells are glial cells of the peripheral nervous system. They exist in several subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are interesting for applications ranging from disease modeling to tissue engineering. Since primary human Schwann cells are challenging to obtain in large quantities, in vitro differentiation from other cell types presents an alternative. Here, we first review the current knowledge on the developmental signaling mechanisms that determine neural crest and Schwann cell differentiation in vivo. Next, an overview of studies on the in vitro differentiation of Schwann cells from multipotent stem cell sources is provided. The molecules frequently used in those protocols and their involvement in the relevant signaling pathways are put into context and discussed. Focusing on hiPSC- and hESC-based studies, different protocols are described and compared, regarding cell sources, differentiation methods, characterization of cells, and protocol efficiency. A brief insight into developments regarding the culture and differentiation of Schwann cells in 3D is given. In summary, this contribution provides an overview of the current resources and methods for the differentiation of Schwann cells, it supports the comparison and refinement of protocols and aids the choice of suitable methods for specific applications.
DOI:doi:10.3390/cells11233753
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/cells11233753
 kostenfrei: Volltext: https://www.mdpi.com/2073-4409/11/23/3753
 DOI: https://doi.org/10.3390/cells11233753
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:differentiation
 glia
 hiPSC
 MSC
 neural crest
 Schwann cells
 stem cells
 tissue engineering
K10plus-PPN:1900840472
Verknüpfungen:→ Zeitschrift

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