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| Verfasst von: | Bahuguna, Shivohum [VerfasserIn]  |
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| | Atilano, Magda [VerfasserIn] |
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| | Glittenberg, Marcus [VerfasserIn] |
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| | Lee, Dohun [VerfasserIn] |
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| | Arora, Srishti [VerfasserIn] |
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| | Wang, Lihui [VerfasserIn] |
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| | Zhou, Jun [VerfasserIn] |
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| | Redhai, Siamak [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| | Ligoxygakis, Petros [VerfasserIn] |
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| Titel: | Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila |
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| Verf.angabe: | Shivohum Bahuguna, Magda Atilano, Marcus Glittenberg, Dohun Lee, Srishti Arora, Lihui Wang, Jun Zhou, Siamak Redhai, Michael Boutros, Petros Ligoxygakis |
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| E-Jahr: | 2022 |
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| Jahr: | January 10, 2022 |
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| Umfang: | 27 S. |
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| Fussnoten: | Gesehen am 03.09.2024 |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS Genetics |
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| Ort Quelle: | San Francisco, Calif. : Public Library of Science, 2005 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 18(2022), 1, Artikel-ID e1009992, Seite 1-27 |
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| ISSN Quelle: | 1553-7404 |
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| Abstract: | The gut sets the immune and metabolic parameters for the survival of commensal bacteria. We report that in Drosophila, deficiency in bacterial recognition upstream of Toll/NF-κB signalling resulted in reduced density and diversity of gut bacteria. Translational regulation factor 4E-BP, a transcriptional target of Toll/NF-κB, mediated this host-bacteriome interaction. In healthy flies, Toll activated 4E-BP, which enabled fat catabolism, which resulted in sustaining of the bacteriome. The presence of gut bacteria kept Toll signalling activity thus ensuring the feedback loop of their own preservation. When Toll activity was absent, TOR-mediated suppression of 4E-BP made fat resources inaccessible and this correlated with loss of intestinal bacterial density. This could be overcome by genetic or pharmacological inhibition of TOR, which restored bacterial density. Our results give insights into how an animal integrates immune sensing and metabolism to maintain indigenous bacteria in a healthy gut. |
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| DOI: | doi:10.1371/journal.pgen.1009992 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1371/journal.pgen.1009992 |
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| | kostenfrei: Volltext: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009992 |
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| | DOI: https://doi.org/10.1371/journal.pgen.1009992 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Errata: Bahuguna, Shivohum, 1997 - : Correction: Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila |
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| Sach-SW: | Catabolism |
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| | Drosophila melanogaster |
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| | Gastrointestinal tract |
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| | Gut bacteria |
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| | Lipids |
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| | Microbial genetics |
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| | Principal component analysis |
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| | Simpson index |
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| K10plus-PPN: | 1900986477 |
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| Verknüpfungen: | → Zeitschrift |
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Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila / Bahuguna, Shivohum [VerfasserIn]; January 10, 2022 (Online-Ressource)
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