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| Verfasst von: | Coraggio, Francesca [VerfasserIn]  |
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| | Bhushan, Mahak [VerfasserIn] |
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| | Roumeliotis, Spyridon [VerfasserIn] |
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| | Caroti, Francesca [VerfasserIn] |
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| | Bevilacqua, Carlo [VerfasserIn] |
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| | Prevedel, Robert [VerfasserIn] |
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| | Rapti, Georgia [VerfasserIn] |
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| Titel: | Age-progressive interplay of HSP-proteostasis, ECM-cell junctions and biomechanics ensures C. elegans astroglial architecture |
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| Verf.angabe: | Francesca Coraggio, Mahak Bhushan, Spyridon Roumeliotis, Francesca Caroti, Carlo Bevilacqua, Robert Prevedel & Georgia Rapti |
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| Jahr: | 2024 |
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| Umfang: | 20 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 3. April 2024 ; Gesehen am 06.09.2024 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 2861, Seite 1-20 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Tissue integrity is sensitive to temperature, tension, age, and is sustained throughout life by adaptive cell-autonomous or extrinsic mechanisms. Safeguarding the remarkably-complex architectures of neurons and glia ensures age-dependent integrity of functional circuits. Here, we report mechanisms sustaining the integrity of C. elegans CEPsh astrocyte-like glia. We combine large-scale genetics with manipulation of genes, cells, and their environment, quantitative imaging of cellular/ subcellular features, tissue material properties and extracellular matrix (ECM). We identify mutants with age-progressive, environment-dependent defects in glial architecture, consequent disruption of neuronal architecture, and abnormal aging. Functional loss of epithelial Hsp70/Hsc70-cochaperone BAG2 causes ECM disruption, altered tissue biomechanics, and hypersensitivity of glia to environmental temperature and mechanics. Glial-cell junctions ensure epithelia-ECM-CEPsh glia association. Modifying glial junctions or ECM mechanics safeguards glial integrity against disrupted BAG2-proteostasis. Overall, we present a finely-regulated interplay of proteostasis-ECM and cell junctions with conserved components that ensures age-progressive robustness of glial architecture. |
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| DOI: | doi:10.1038/s41467-024-46827-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-024-46827-2 |
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| | Volltext: https://www.nature.com/articles/s41467-024-46827-2 |
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| | DOI: https://doi.org/10.1038/s41467-024-46827-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Astrocyte |
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| | Extracellular matrix |
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| | Morphogenesis |
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| | Protein quality control |
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| K10plus-PPN: | 1902115406 |
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| Verknüpfungen: | → Zeitschrift |
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Age-progressive interplay of HSP-proteostasis, ECM-cell junctions and biomechanics ensures C. elegans astroglial architecture / Coraggio, Francesca [VerfasserIn]; 2024 (Online-Ressource)
