Perindopril alleviates inflammation via Cyclooxygenase inhibition

• Verfasst von: El Sebaei, Mahmoud [VerfasserIn]
• Verfasst von: Zabady, Mohamed Karam [VerfasserIn]
• Verfasst von: Ghonim, Ibrahim [VerfasserIn]
• Verfasst von: Hereba, Abdulrahman Taha [VerfasserIn]
• Verfasst von: Abdelghany, Ahmed Meligy [VerfasserIn]
• Verfasst von: El-Bahr, Sabry Mohamed [VerfasserIn]
• Verfasst von: Gaballa, Mohamed Mahmoud Salem Ahmed [VerfasserIn]
• Verfasst von: Kandeel, Mahmoud [VerfasserIn]
• Titel: Perindopril alleviates inflammation via Cyclooxygenase inhibition
• Titelzusatz: a bioinformatics, in vitro and in vivo evaluation
• Verf.angabe: Mahmoud El Sebaei, Mohamed Karam Zabady, Ibrahim Ghonim, Abdulrahman Taha Hereba, Ahmed Meligy Abdelghany, Sabry Mohamed El-Bahr, Mohamed Mahmoud Salem Gaballa and Mahmoud Kandeel
• Jahr: 2023
• Umfang: 12 S.
• Fussnoten: Gesehen am 09.09.2024
• Titel Quelle: Enthalten in: International journal of pharmacology
• Ort Quelle: Faisalābād : Asian Network for Scientific Information, 2005
• Jahr Quelle: 2023
• Band/Heft Quelle: 19(2023), 3, Seite 428-438
• ISSN Quelle: 1812-5700
• DOI: doi:10.3923/ijp.2023.428.438
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1902192249

Abstract

Background and Objective: Perindopril (PER), an angiotensin-converting enzyme (ACE) inhibitor with anti-apoptotic, antioxidant and anti-inflammatory characteristics, has long been used to treat cardiovascular illnesses. In this study, the enzyme inhibitory activity of PER against Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) was determined. Materials and Methods: The PERʼs anti-inflammatory actions were estimated by in vitro COX-1 and COX-2 inhibition assays, the in vivo rat model of carrageenan-induced paw edema, histopathological examination, molecular modeling, docking and molecular dynamics studies. The data were analyzed using the Analysis of Variance (ANOVA) Test. Results: The PER IC50 values for COX-1 and COX-2 were calculated to be 8.3 and 0.1 µM, respectively, showing that PER has an 85.5-fold higher affinity for COX-2 than for COX-1. The PER was found to be a moderate inflammation suppressor in rat paw assay, comparable to celecoxib and indomethacin. Docking and molecular dynamics (MD) simulation supported the stable binding of PER with COX-2. Conclusion: Current findings revealed that PER can be used for local acute inflammation and utilized as a substitute for other topical anti-inflammatory medicines, particularly those containing steroids.