| Online-Ressource |
Verfasst von: | Reichert, Simon [VerfasserIn]  |
| Schepkin, Victor [VerfasserIn]  |
| Kleimaier, Dennis [VerfasserIn]  |
| Zöllner, Frank G. [VerfasserIn]  |
| Schad, Lothar R. [VerfasserIn]  |
Titel: | Sodium triple quantum MR signal extraction using a single-pulse sequence with single quantum time efficiency |
Verf.angabe: | Simon Reichert, Victor Schepkin, Dennis Kleimaier, Frank G. Zöllner, Lothar R. Schad |
E-Jahr: | 2024 |
Jahr: | September 2024 |
Umfang: | 16 S. |
Fussnoten: | Online veröffentlicht: 22. April 2024 ; Gesehen am 11.09.2024 |
Titel Quelle: | Enthalten in: Magnetic resonance in medicine |
Ort Quelle: | New York, NY [u.a.] : Wiley-Liss, 1984 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 92(2024), 3 vom: Sept., Seite 900-915 |
ISSN Quelle: | 1522-2594 |
Abstract: | Purpose Sodium triple quantum (TQ) signal has been shown to be a valuable biomarker for cell viability. Despite its clinical potential, application of Sodium TQ signal is hindered by complex pulse sequences with long scan times. This study proposes a method to approximate the TQ signal using a single excitation pulse without phase cycling. Methods The proposed method is based on a single excitation pulse and a comparison of the free induction decay (FID) with the integral of the FID combined with a shifting reconstruction window. The TQ signal is calculated from this FID only. As a proof of concept, the method was also combined with a multi-echo UTE imaging sequence on a 9.4 T preclinical MRI scanner for the possibility of fast TQ MRI. Results The extracted Sodium TQ signals of single-pulse and spin echo FIDs were in close agreement with theory and TQ measurement by traditional three-pulse sequence (TQ time proportional phase increment [TQTPPI)]. For 2%, 4%, and 6% agar samples, the absolute deviations of the maximum TQ signals between SE and theoretical (time proportional phase increment TQTPPI) TQ signals were less than 1.2% (2.4%), and relative deviations were less than 4.6% (6.8%). The impact of multi-compartment systems and noise on the accuracy of the TQ signal was small for simulated data. The systematic error was <3.4% for a single quantum (SQ) SNR of 5 and at maximum <2.5% for a multi-compartment system. The method also showed the potential of fast in vivo SQ and TQ imaging. Conclusion Simultaneous SQ and TQ MRI using only a single-pulse sequence and SQ time efficiency has been demonstrated. This may leverage the full potential of the Sodium TQ signal in clinical applications. |
DOI: | doi:10.1002/mrm.30107 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/mrm.30107 |
| kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.30107 |
| DOI: https://doi.org/10.1002/mrm.30107 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | multi-quantum |
| multiple quantum coherences |
| Sodium MRI |
| sodium triple quantum coherences |
| SodiumTQ |
K10plus-PPN: | 1902314565 |
Verknüpfungen: | → Zeitschrift |
Sodium triple quantum MR signal extraction using a single-pulse sequence with single quantum time efficiency / Reichert, Simon [VerfasserIn]; September 2024 (Online-Ressource)