Sodium triple quantum MR signal extraction using a single-pulse sequence with single quantum time efficiency

• Verfasst von: Reichert, Simon [VerfasserIn]
• Verfasst von: Schepkin, Victor [VerfasserIn]
• Verfasst von: Kleimaier, Dennis [VerfasserIn]
• Verfasst von: Zöllner, Frank G. [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Titel: Sodium triple quantum MR signal extraction using a single-pulse sequence with single quantum time efficiency
• Verf.angabe: Simon Reichert, Victor Schepkin, Dennis Kleimaier, Frank G. Zöllner, Lothar R. Schad
• E-Jahr: 2024
• Jahr: September 2024
• Umfang: 16 S.
• Fussnoten: Online veröffentlicht: 22. April 2024 ; Gesehen am 11.09.2024
• Titel Quelle: Enthalten in: Magnetic resonance in medicine
• Ort Quelle: New York, NY [u.a.] : Wiley-Liss, 1984
• Jahr Quelle: 2024
• Band/Heft Quelle: 92(2024), 3 vom: Sept., Seite 900-915
• ISSN Quelle: 1522-2594
• DOI: doi:10.1002/mrm.30107
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: multi-quantum
• Sach-SW: multiple quantum coherences
• Sach-SW: Sodium MRI
• Sach-SW: sodium triple quantum coherences
• Sach-SW: SodiumTQ
• K10plus-PPN: 1902314565

Abstract

Purpose Sodium triple quantum (TQ) signal has been shown to be a valuable biomarker for cell viability. Despite its clinical potential, application of Sodium TQ signal is hindered by complex pulse sequences with long scan times. This study proposes a method to approximate the TQ signal using a single excitation pulse without phase cycling. Methods The proposed method is based on a single excitation pulse and a comparison of the free induction decay (FID) with the integral of the FID combined with a shifting reconstruction window. The TQ signal is calculated from this FID only. As a proof of concept, the method was also combined with a multi-echo UTE imaging sequence on a 9.4 T preclinical MRI scanner for the possibility of fast TQ MRI. Results The extracted Sodium TQ signals of single-pulse and spin echo FIDs were in close agreement with theory and TQ measurement by traditional three-pulse sequence (TQ time proportional phase increment [TQTPPI)]. For 2%, 4%, and 6% agar samples, the absolute deviations of the maximum TQ signals between SE and theoretical (time proportional phase increment TQTPPI) TQ signals were less than 1.2% (2.4%), and relative deviations were less than 4.6% (6.8%). The impact of multi-compartment systems and noise on the accuracy of the TQ signal was small for simulated data. The systematic error was <3.4% for a single quantum (SQ) SNR of 5 and at maximum <2.5% for a multi-compartment system. The method also showed the potential of fast in vivo SQ and TQ imaging. Conclusion Simultaneous SQ and TQ MRI using only a single-pulse sequence and SQ time efficiency has been demonstrated. This may leverage the full potential of the Sodium TQ signal in clinical applications.