| |  Online-Ressource |
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| Verfasst von: | Knipping, Eckart [VerfasserIn]  |
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| | Debatin, Klaus-Michael [VerfasserIn] |
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| | Stricker, Kirstin [VerfasserIn] |
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| | Heilig, Bernhard [VerfasserIn] |
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| | Eder, Astrid [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| Titel: | Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias |
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| Verf.angabe: | Eckart Knipping, Klaus-Michael Debatin, Kirstin Stricker, Bernhard Heilig, Astrid Eder, Peter H. Krammer |
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| E-Jahr: | 1995 |
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| Jahr: | 15 March 1995 |
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| Umfang: | 8 S. |
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| Fussnoten: | Elektronische Reproduktion der Druck-Ausgabe 21. Dezember 2020 ; Version of record: 21 December 2020 ; Gesehen am 11.09.2024 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 1995 |
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| Band/Heft Quelle: | 85(1995), 6, Seite 1562-1569 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | The cell-surface protein APO-1 is a member of the nerve growth factor (NGF)/tumor necrosis factor (TNF) receptor superfamily. APO-1 mediates apoptosis in susceptible cells upon stimulation with the monoclonal antibody anti-APO-1 or upon binding of its natural ligand. Soluble receptors had previously been identified for most members of the NGF/TNF receptor superfamily. Recently, a soluble form of APO-1 (sAPO-1) was described. We established a sandwich enzyme-linked immunosorbent assay to detect sAPO-1 in culture supernatants of human cell lines and in human sera. sAPO-1 was found in culture supernatants of different human B- and T-cell lines. Molecular weights of sAP0-1 and membrane APO-1 were similar. In addition, in comparison to healthy donors, sera from patients with different highland low-grade malignant B- and T-cell leukemias and lymphomas contained increased levels of sAP0-1. These findings may have implications for the growth of leukemias and the diagnostic monitoring of individual patients. |
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| DOI: | doi:10.1182/blood.V85.6.1562.bloodjournal8561562 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood.V85.6.1562.bloodjournal8561562 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0006497120687675 |
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| | DOI: https://doi.org/10.1182/blood.V85.6.1562.bloodjournal8561562 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1902344898 |
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| Verknüpfungen: | → Zeitschrift |
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Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias / Knipping, Eckart [VerfasserIn]; 15 March 1995 (Online-Ressource)
