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| Verfasst von: | Sachse, Marco [VerfasserIn]  |
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| | Tual-Chalot, Simon [VerfasserIn] |
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| | Ciliberti, Giorgia [VerfasserIn] |
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| | Amponsah-Offeh, Michael [VerfasserIn] |
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| | Stamatelopoulos, Kimon [VerfasserIn] |
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| | Gatsiou, Aikaterini [VerfasserIn] |
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| | Stellos, Konstantinos [VerfasserIn] |
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| Titel: | RNA-binding proteins in vascular inflammation and atherosclerosis |
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| Verf.angabe: | Marco Sachse, Simon Tual-Chalot, Giorgia Ciliberti, Michael Amponsah-Offeh, Kimon Stamatelopoulos, Aikaterini Gatsiou, Konstantinos Stellos |
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| E-Jahr: | 2023 |
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| Jahr: | June 2023 |
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| Umfang: | 19 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 17. Januar 2023, Artikelversion: 15. Juni 2023 ; Gesehen am 11.09.2024 |
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| Titel Quelle: | Enthalten in: Atherosclerosis |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1970 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 374(2023), Seite 55-73 |
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| ISSN Quelle: | 1879-1484 |
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| Abstract: | Atherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability worldwide, even when patients with an established manifestation of atherosclerotic heart disease are optimally treated according to the clinical guidelines. Apart from the epigenetic control of transcription of the genetic information to messenger RNAs (mRNAs), gene expression is tightly controlled at the post-transcriptional level before the initiation of translation. Although mRNAs are traditionally perceived as the messenger molecules that bring genetic information from the nuclear DNA to the cytoplasmic ribosomes for protein synthesis, emerging evidence suggests that processes controlling RNA metabolism, driven by RNA-binding proteins (RBPs), affect cellular function in health and disease. Over the recent years, vascular endothelial cell, smooth muscle cell and immune cell RBPs have emerged as key co- or post-transcriptional regulators of several genes related to vascular inflammation and atherosclerosis. In this review, we provide an overview of cell-specific function of RNA-binding proteins involved in all stages of ASCVD and how this knowledge may be used for the development of novel precision medicine therapeutics. |
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| DOI: | doi:10.1016/j.atherosclerosis.2023.01.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.atherosclerosis.2023.01.008 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0021915023000096 |
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| | DOI: https://doi.org/10.1016/j.atherosclerosis.2023.01.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Atherosclerosis |
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| | Endothelial cell |
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| | Immune cell |
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| | Inflammation |
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| | RNA-binding proteins |
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| | Smooth muscle cell |
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| K10plus-PPN: | 1902351967 |
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| Verknüpfungen: | → Zeitschrift |
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RNA-binding proteins in vascular inflammation and atherosclerosis / Sachse, Marco [VerfasserIn]; June 2023 (Online-Ressource)
