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| Verfasst von: | Guièze, Romain [VerfasserIn]  |
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| | Eikema, Diderik-Jan [VerfasserIn] |
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| | Koster, Linda [VerfasserIn] |
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| | Schetelig, Johannes [VerfasserIn] |
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| | Sengeloev, Henrik [VerfasserIn] |
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| | Passweg, Jakob R. [VerfasserIn] |
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| | Finke, Jürgen [VerfasserIn] |
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| | Arat, Mutlu [VerfasserIn] |
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| | Broers, Annoek E. C. [VerfasserIn] |
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| | Stölzel, Friedrich [VerfasserIn] |
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| | Byrne, Jenny [VerfasserIn] |
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| | Castilla-Llorente, Cristina [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Eder, Matthias [VerfasserIn] |
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| | Gedde-Dahl, Tobias [VerfasserIn] |
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| | Kröger, Nicolaus [VerfasserIn] |
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| | Ribera Santasusana, Josep Maria [VerfasserIn] |
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| | Richardson, Deborah [VerfasserIn] |
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| | Rambaldi, Alessandro [VerfasserIn] |
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| | Yañez, Lucrecia [VerfasserIn] |
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| | Van Gelder, Michel [VerfasserIn] |
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| | Drozd-Sokolowska, Joanna [VerfasserIn] |
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| | Raj, Kavita [VerfasserIn] |
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| | Yakoub-Agha, Ibrahim [VerfasserIn] |
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| | Tournilhac, Olivier [VerfasserIn] |
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| | McLornan, Donal [VerfasserIn] |
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| Titel: | Allogeneic hematopoietic stem-cell transplantation for patients with Richter transformation |
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| Titelzusatz: | a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT |
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| Verf.angabe: | Romain Guièze, Diderik-Jan Eikema, Linda Koster, Johannes Schetelig, Henrik Sengeloev, Jakob Passweg, Jürgen Finke, Mutlu Arat, Annoek E.C. Broers, Friedrich Stölzel, Jenny Byrne, Cristina Castilla-Llorente, Peter Dreger, Matthias Eder, Tobias Gedde-Dahl, Nicolaus Kröger, Josep Maria Ribera Santasusana, Deborah Richardson, Alessandro Rambaldi, Lucrecia Yañez, Michel Van Gelder, Joanna Drozd-Sokolowska, Kavita Raj, Ibrahim Yakoub-Agha, Olivier Tournilhac and Donal P. McLornan |
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| E-Jahr: | 2024 |
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| Jahr: | 19 March 2024 |
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| Umfang: | 7 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 13.09.2024 |
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| Titel Quelle: | Enthalten in: Bone marrow transplantation |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 59(2024), 7, Seite 950-956 |
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| ISSN Quelle: | 1476-5365 |
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| Abstract: | Management of Richter transformation (RT) is particularly challenging, with survival estimates <1 year. We report on outcomes of 66 RT patients undergoing allogeneic-HCT (allo-HCT) between 2008 and 2018 registered with the EBMT. Median age at allo-HCT was 56.2 years (interquartile range (IQR), 51.3-63.1). Median time from RT to allo-HCT was 6.9 months (IQR, 4.9-11) and 28 (42.4%) were in complete remission (CR). The majority underwent reduced intensity conditioning (66.2%) using peripheral blood derived stem cells. Eighteen (27.3%) patients had a matched sibling donor, 24 (36.4%) a matched unrelated donor and the remaining were mismatched. Median follow-up was 6.6 years; 1- and 3- year overall and progression free survival (PFS) (95% CI) was 65% (54-77) and 39% (27-51) and 53% (41-65) and 29% (18-40), respectively. Patients in CR at time of allo-HCT had significantly better 3-year PFS (39% vs. 21%, p = 0.032). Cumulative incidences of grade II-IV acute graft versus host disease (GVHD) at day +100 was 41% (95% CI 29-53) and chronic GVHD at 3 years was 53% (95% CI 41-65). High rates of non-relapse mortality (NRM) were observed; 38% (95% CI, 26-50) at 3 years. Although potentially curative, approaches to reduce considerable NRM and chronic GVHD rates are required. |
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| DOI: | doi:10.1038/s41409-024-02256-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41409-024-02256-9 |
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| | Volltext: https://www.nature.com/articles/s41409-024-02256-9 |
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| | DOI: https://doi.org/10.1038/s41409-024-02256-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | B-cell lymphoma |
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| | Stem-cell therapies |
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| K10plus-PPN: | 190251923X |
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| Verknüpfungen: | → Zeitschrift |
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Allogeneic hematopoietic stem-cell transplantation for patients with Richter transformation / Guièze, Romain [VerfasserIn]; 19 March 2024 (Online-Ressource)
