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Verfasst von:Grünewald, Thomas G. P. [VerfasserIn]   i
 Postel-Vinay, Sophie [VerfasserIn]   i
 Nakayama, Robert T. [VerfasserIn]   i
 Berlow, Noah E. [VerfasserIn]   i
 Bolzicco, Andrea [VerfasserIn]   i
 Cerullo, Vincenzo [VerfasserIn]   i
 Dermawan, Josephine K. [VerfasserIn]   i
 Frezza, Anna Maria [VerfasserIn]   i
 Italiano, Antoine [VerfasserIn]   i
 Jin, Jia Xiang [VerfasserIn]   i
 Le Loarer, Francois [VerfasserIn]   i
 Martin-Broto, Javier [VerfasserIn]   i
 Pecora, Andrew [VerfasserIn]   i
 Perez-Martinez, Antonio [VerfasserIn]   i
 Tam, Yuen Bun [VerfasserIn]   i
 Tirode, Franck [VerfasserIn]   i
 Trama, Annalisa [VerfasserIn]   i
 Pasquali, Sandro [VerfasserIn]   i
 Vescia, Mariagrazia [VerfasserIn]   i
 Wortmann, Lukas [VerfasserIn]   i
 Wortmann, Michael [VerfasserIn]   i
 Yoshida, Akihiko [VerfasserIn]   i
 Webb, Kim [VerfasserIn]   i
 Huang, Paul H. [VerfasserIn]   i
 Keller, Charles [VerfasserIn]   i
 Antonescu, Cristina R. [VerfasserIn]   i
Titel:Translational aspects of epithelioid sarcoma
Titelzusatz:current consensus
Verf.angabe:Thomas G.P. Grünewald, Sophie Postel-Vinay, Robert T. Nakayama, Noah E. Berlow, Andrea Bolzicco, Vincenzo Cerullo, Josephine K. Dermawan, Anna Maria Frezza, Antoine Italiano, Jia Xiang Jin, Francois Le Loarer, Javier Martin-Broto, Andrew Pecora, Antonio Perez-Martinez, Yuen Bun Tam, Franck Tirode, Annalisa Trama, Sandro Pasquali, Mariagrazia Vescia, Lukas Wortmann, Michael Wortmann, Akihiko Yoshida, Kim Webb, Paul H. Huang, Charles Keller, and Cristina R. Antonescu
E-Jahr:2024
Jahr:15 March 2024
Umfang:14 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 13.09.2024
Titel Quelle:Enthalten in: Clinical cancer research
Ort Quelle:Philadelphia, Pa. [u.a.] : AACR, 1995
Jahr Quelle:2024
Band/Heft Quelle:30(2024), 6 vom: März, Seite 1079-1092
ISSN Quelle:1557-3265
Abstract:Epithelioid sarcoma (EpS) is an ultra-rare malignant soft-tissue cancer mostly affecting adolescents and young adults. EpS often exhibits an unfavorable clinical course with fatal outcome in ∼50% of cases despite aggressive multimodal therapies combining surgery, chemotherapy, and irradiation. EpS is traditionally classified in a more common, less aggressive distal (classic) type and a rarer aggressive proximal type. Both subtypes are characterized by a loss of nuclear INI1 expression, most often following homozygous deletion of its encoding gene, SMARCB1—a core subunit of the SWI/SNF chromatin remodeling complex. In 2020, the EZH2 inhibitor tazemetostat was the first targeted therapy approved for EpS, raising new hopes. Still, the vast majority of patients did not benefit from this drug or relapsed rapidly. Further, other recent therapeutic modalities, including immunotherapy, are only effective in a fraction of patients. Thus, novel strategies, specifically targeted to EpS, are urgently needed. To accelerate translational research on EpS and eventually boost the discovery and development of new diagnostic tools and therapeutic options, a vibrant translational research community has formed in past years and held two international EpS digital expert meetings in 2021 and 2023. This review summarizes our current understanding of EpS from the translational research perspective and points to innovative research directions to address the most pressing questions in the field, as defined by expert consensus and patient advocacy groups.
DOI:doi:10.1158/1078-0432.CCR-23-2174
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1158/1078-0432.CCR-23-2174
 DOI: https://doi.org/10.1158/1078-0432.CCR-23-2174
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1902523334
Verknüpfungen:→ Zeitschrift

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