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| Verfasst von: | Mayrhofer-Schmid, Maximilian [VerfasserIn]  |
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| | Aman, Martin [VerfasserIn] |
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| | Panayi, Adriana C. [VerfasserIn] |
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| | Raasveld, Floris V. [VerfasserIn] |
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| | Kneser, Ulrich [VerfasserIn] |
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| | Eberlin, Kyle R. [VerfasserIn] |
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| | Harhaus-Wähner, Leila [VerfasserIn] |
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| | Böcker, Arne Hendrik [VerfasserIn] |
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| Titel: | Fibrin glue coating limits scar tissue formation around peripheral nerves |
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| Verf.angabe: | Maximilian Mayrhofer-Schmid, Martin Aman, Adriana C. Panayi, Floris V. Raasveld, Ulrich Kneser, Kyle R. Eberlin, Leila Harhaus and Arne Böcker |
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| E-Jahr: | 2024 |
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| Jahr: | 26 March 2024 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 16.09.2024 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 25(2024), 7, Artikel-ID 3687, Seite 1-13 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Scar tissue formation presents a significant barrier to peripheral nerve recovery in clinical practice. While different experimental methods have been described, there is no clinically available gold standard for its prevention. This study aims to determine the potential of fibrin glue (FG) to limit scarring around peripheral nerves. Thirty rats were divided into three groups: glutaraldehyde-induced sciatic nerve injury treated with FG (GA + FG), sciatic nerve injury with no treatment (GA), and no sciatic nerve injury (Sham). Neural regeneration was assessed with weekly measurements of the visual static sciatic index as a parameter for sciatic nerve function across a 12-week period. After 12 weeks, qualitative and quantitative histological analysis of scar tissue formation was performed. Furthermore, histomorphometric analysis and wet muscle weight analysis were performed after the postoperative observation period. The GA + FG group showed a faster functional recovery (6 versus 9 weeks) compared to the GA group. The FG-treated group showed significantly lower perineural scar tissue formation and significantly higher fiber density, myelin thickness, axon thickness, and myelinated fiber thickness than the GA group. A significantly higher wet muscle weight ratio of the tibialis anterior muscle was found in the GA + FG group compared to the GA group. Our results suggest that applying FG to injured nerves is a promising scar tissue prevention strategy associated with improved regeneration both at the microscopic and at the functional level. Our results can serve as a platform for innovation in the field of perineural regeneration with immense clinical potential. |
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| DOI: | doi:10.3390/ijms25073687 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms25073687 |
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| | Volltext: https://www.mdpi.com/1422-0067/25/7/3687 |
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| | DOI: https://doi.org/10.3390/ijms25073687 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomaterials |
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| | microsurgery |
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| | nerve adhesions |
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| | nerve regeneration |
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| | nerve scarring |
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| | nerve surgery |
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| | peripheral nerve injury |
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| K10plus-PPN: | 1902570804 |
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| Verknüpfungen: | → Zeitschrift |
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Fibrin glue coating limits scar tissue formation around peripheral nerves / Mayrhofer-Schmid, Maximilian [VerfasserIn]; 26 March 2024 (Online-Ressource)
