Vaccination protects against acute respiratory distress syndrome (ARDS) in hospitalized patients with COVID-19

• Verfasst von: Madrid, Julian [VerfasserIn]
• Verfasst von: Agarwal, Prerana [VerfasserIn]
• Verfasst von: Müller-Peltzer, Katharina [VerfasserIn]
• Verfasst von: Askani, Marvin [VerfasserIn]
• Verfasst von: Benning, Leo [VerfasserIn]
• Verfasst von: Selig, Mischa [VerfasserIn]
• Verfasst von: Diehl, Philipp [VerfasserIn]
• Verfasst von: Kalbhenn, Johannes [VerfasserIn]
• Verfasst von: Trummer, Georg [VerfasserIn]
• Verfasst von: Utzolino, Stefan [VerfasserIn]
• Verfasst von: Wengenmayer, Tobias [VerfasserIn]
• Verfasst von: Busch, Hans-Jörg [VerfasserIn]
• Verfasst von: Stolz, Daiana [VerfasserIn]
• Verfasst von: Rieg, Siegbert [VerfasserIn]
• Verfasst von: Panning, Marcus [VerfasserIn]
• Verfasst von: Schlett, Christopher L. [VerfasserIn]
• Verfasst von: Bamberg, Fabian [VerfasserIn]
• Verfasst von: Askani, Esther Adele [VerfasserIn]
• Titel: Vaccination protects against acute respiratory distress syndrome (ARDS) in hospitalized patients with COVID-19
• Verf.angabe: Julian Madrid, Prerana Agarwal, Katharina Müller-Peltzer, Marvin Askani, Leo Benning, Mischa Selig, Philipp Diehl, Johannes Kalbhenn, Georg Trummer, Stefan Utzolino, Tobias Wengenmayer, Hans-Jörg Busch, Daiana Stolz, Siegbert Rieg, Marcus Panning, Christopher L. Schlett, Fabian Bamberg, Esther Askani
• E-Jahr: 2024
• Jahr: 27 January 2024
• Umfang: 16 S.
• Fussnoten: Gesehen am 16.09.2024
• Titel Quelle: Enthalten in: Clinical and experimental medicine
• Ort Quelle: Milano : Springer, 2001
• Jahr Quelle: 2024
• Band/Heft Quelle: 24(2024), 1, Artikel-ID 21, Seite 1-16
• ISSN Quelle: 1591-9528
• DOI: doi:10.1007/s10238-023-01293-w
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ARDS
• Sach-SW: COVID-19
• Sach-SW: Hospitalization
• Sach-SW: Vaccination
• K10plus-PPN: 1902599772

Abstract

This study aimed to analyze the effect of COVID-19 vaccination on the occurrence of ARDS in hospitalized COVID-19 patients. The study population of this retrospective, single-center cohort study consisted of hospitalized COVID-19 patients with known vaccination status and chest computed tomography imaging between July 2021 and February 2022. The impact of vaccination on ARDS in COVID-19 patients was assessed through logistic regression adjusting for demographic differences and confounding factors with statistical differences determined using confidence intervals and effect sizes. A total of 167 patients (69% male, average age 58 years, 95% CI [55; 60], 42% fully vaccinated) were included in the data analysis. Vaccinated COVID-19 patients had a reduced relative risk (RR) of developing ARDS (RR: 0.40, 95% CI [0.21; 0.62]). Consequently, non-vaccinated hospitalized patients had a 2.5-fold higher probability of developing ARDS. This risk reduction persisted after adjusting for several confounding variables (RR: 0.64, 95% CI [0.29; 0.94]) in multivariate analysis. The protective effect of COVID-19 vaccination increased with ARDS severity (RR: 0.61, 95% CI [0.37; 0.92]). Particularly, patients under 60 years old were at risk for ARDS onset and seemed to benefit from COVID-19 vaccination (RR: 0.51, 95% CI [0.20; 0.90]). COVID-19 vaccination showed to reduce the risk of ARDS occurrence in hospitalized COVID-19 patients, with a particularly strong effect in patients under 60 years old and those with more severe ARDS.