Surgery of motor eloquent glioblastoma guided by TMS-informed tractography

• Verfasst von: Weiß Lucas, Carolin [VerfasserIn]
• Verfasst von: Faymonville, Andrea M. [VerfasserIn]
• Verfasst von: Loução, Ricardo [VerfasserIn]
• Verfasst von: Schroeter, Catharina [VerfasserIn]
• Verfasst von: Nettekoven, Charlotte [VerfasserIn]
• Verfasst von: Oros-Peusquens, Ana-Maria [VerfasserIn]
• Verfasst von: Langen, Karl Josef [VerfasserIn]
• Verfasst von: Shah, N. Jon [VerfasserIn]
• Verfasst von: Stoffels, Gabriele [VerfasserIn]
• Verfasst von: Neuschmelting, Volker [VerfasserIn]
• Verfasst von: Blau, Tobias [VerfasserIn]
• Verfasst von: Neuschmelting, Hannah [VerfasserIn]
• Verfasst von: Hellmich, Martin [VerfasserIn]
• Verfasst von: Kocher, Martin [VerfasserIn]
• Verfasst von: Grefkes, Christian [VerfasserIn]
• Verfasst von: Goldbrunner, Roland [VerfasserIn]
• Titel: Surgery of motor eloquent glioblastoma guided by TMS-informed tractography
• Titelzusatz: driving resection completeness towards prolonged survival
• Verf.angabe: Carolin Weiss Lucas, Andrea Maria Faymonville, Ricardo Loução, Catharina Schroeter, Charlotte Nettekoven, Ana-Maria Oros-Peusquens, Karl Josef Langen, N. Jon Shah, Gabriele Stoffels, Volker Neuschmelting, Tobias Blau, Hannah Neuschmelting, Martin Hellmich, Martin Kocher, Christian Grefkes and Roland Goldbrunner
• E-Jahr: 2022
• Jahr: 27 May 2022
• Umfang: 18 S.
• Fussnoten: Gesehen am 17.09.2024
• Titel Quelle: Enthalten in: Frontiers in oncology
• Ort Quelle: Lausanne : Frontiers Media, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), Artikel-ID 874631, Seite 1-18
• ISSN Quelle: 2234-943X
• DOI: doi:10.3389/fonc.2022.874631
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: CST
• Sach-SW: Diffusion Tensor Imaging
• Sach-SW: DTI
• Sach-SW: functional outcome
• Sach-SW: HGG
• Sach-SW: high grade glioma
• Sach-SW: Rolandic
• Sach-SW: Transcranial Magnetic Stimulation
• K10plus-PPN: 190272187X

Abstract

Background Surgical treatment of patients with glioblastoma affecting motor eloquent brain regions remains critically discussed given the risk-benefit dilemma of prolonging survival at the cost of motor-functional damage. Tractography informed by navigated transcranial magnetic stimulation (nTMS-informed tractography, TIT) provides a rather robust estimate of the individual location of the corticospinal tract (CST), a highly vulnerable structure with poor functional reorganisation potential. We hypothesised that by a more comprehensive, individualised surgical decision-making using TIT, tumours in close relationship to the CST can be resected with at least equal probability of gross total resection (GTR) than less eloquently located tumours without causing significantly more gross motor function harm. Moreover, we explored whether the completeness of TIT-aided resection translates to longer survival. Methods A total of 61 patients (median age 63 years, m = 34) with primary glioblastoma neighbouring or involving the CST were operated on between 2010 and 2015. TIT was performed to inform surgical planning in 35 of the patients (group T; vs. 26 control patients). To achieve largely unconfounded group comparisons for each co-primary outcome (i.e., gross-motor functional worsening, GTR, survival), (i) uni- and multivariate regression analyses were performed to identify features of optimal outcome prediction; (ii), optimal propensity score matching (PSM) was applied to balance those features pairwise across groups, followed by (iii) pairwise group comparison. Results Patients in group T featured a significantly higher lesion-CST overlap compared to controls (8.7 ± 10.7% vs. 3.8 ± 5.7%; p = 0.022). The frequency of gross motor worsening was higher in group T, albeit non-significant (n = 5/35 vs. n = 0/26; p = 0.108). PSM-based paired-sample comparison, controlling for the confounders of preoperative tumour volume and vicinity to the delicate vasculature of the insula, showed higher GTR rates in group T (77% vs. 69%; p = 0.025), particularly in patients with a priori intended GTR (87% vs. 78%; p = 0.003). This translates into a prolonged PFS in the same PSM subgroup (8.9 vs. 5.8 months; p = 0.03), with GTR representing the strongest predictor of PFS (p = 0.001) and OS (p = 0.0003) overall. Conclusion The benefit of TIT-aided GTR appears to overcome the drawbacks of potentially elevated motor functional risk in motor eloquent tumour localisation, leading to prolonged survival of patients with primary glioblastoma close to the CST.