| |  Online-Ressource |
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| Verfasst von: | Westendorp, Michael [VerfasserIn]  |
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| | Frank, Rainer [VerfasserIn] |
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| | Ochsenbauer, Christina [VerfasserIn] |
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| | Stricker, Kirstin [VerfasserIn] |
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| | Dhein, Jens [VerfasserIn] |
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| | Walczak, Henning [VerfasserIn] |
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| | Debatin, Klaus-Michael [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| Titel: | Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120 |
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| Verf.angabe: | Michael O. Westendorp, Rainer Frank, Christina Ochsenbauer, Kirstin Stricker, Jens Dhein, Henning Walczak, Klaus-Michael Debating, Peter H. Krammer |
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| E-Jahr: | 1995 |
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| Jahr: | 08 June 1995 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 17.09.2024 |
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| Titel Quelle: | Enthalten in: Nature |
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| Ort Quelle: | London [u.a.] : Nature Publ. Group, 1869 |
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| Jahr Quelle: | 1995 |
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| Band/Heft Quelle: | 375(1995), 6531, Seite 497-500 |
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| ISSN Quelle: | 1476-4687 |
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| Abstract: | THE depletion of CD4+ T cells in AIDS is correlated with high turnover of the human immunodeficiency virus HIV-1,2 and associated with apoptosis3-5. The molecular mechanism of apoptosis in HIV infection, however, is largely unknown. T-cell apoptosis might be affected by viral proteins such as HIV-1 Tat6-9 and gp120 (refs 10, 11). T-cell-receptor (TCR)-induced apoptosis was recently shown to involve the CD95 (APO-1/Fas) receptor12. We show here that HIV-1 Tat strongly sensitizes TCR- and CD4(gpl20)-induced apoptosis by upregulation of CD95 ligand expression. Concentrations of Tat found to be effective in cultures of HIV-1-infected cells were also observed in sera from HIV-1-infected individuals. Taken together, our results indicate that HIV-1 Tat and gp!20 accelerate CD95-mediated, activation-induced T-cell apoptosis, a mechanism that may contribute to CD4+T-cell depletion5,13,14 in AIDS. |
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| DOI: | doi:10.1038/375497a0 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/375497a0 |
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| | Volltext: https://www.nature.com/articles/375497a0 |
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| | DOI: https://doi.org/10.1038/375497a0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Humanities and Social Sciences |
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| | multidisciplinary |
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| | Science |
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| K10plus-PPN: | 190273162X |
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| Verknüpfungen: | → Zeitung |
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Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120 / Westendorp, Michael [VerfasserIn]; 08 June 1995 (Online-Ressource)
