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| Verfasst von: | Khalilzadeh, Emad [VerfasserIn]  |
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| | Aliyoldashi, Mohammadhassan [VerfasserIn] |
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| | Abdkarimi, Babak [VerfasserIn] |
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| | Azarpey, Farzin [VerfasserIn] |
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| | Vafaei Saiah, Gholamreza [VerfasserIn] |
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| | Hazrati, Reza [VerfasserIn] |
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| | Caspani, Ombretta [VerfasserIn] |
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| Titel: | Reversal of cold intolerance by testosterone in orchiectomized mice after tibial nerve transection |
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| Verf.angabe: | Emad Khalilzadeh, Mohammadhassan Aliyoldashi, Babak Abdkarimi, Farzin Azarpey, Gholamreza Vafaei Saiah, Reza Hazrati, Ombretta Caspani |
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| E-Jahr: | 2023 |
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| Jahr: | 12 March 2023 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 24. Dezember 2022, Artikelversion: 5. Januar 2023 ; Gesehen am 19.09.2024 |
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| Titel Quelle: | Enthalten in: Behavioural brain research |
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| Ort Quelle: | Amsterdam : Elsevier, 1980 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 441(2023), Artikel-ID 114269, Seite 1-11 |
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| ISSN Quelle: | 1872-7549 |
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| Abstract: | Cold intolerance is a debilitating effect of nerve injury, has a strong impact on the life of patients and no advisable treatment exists against it. Testosterone influences pain pathways and has analgesic effects. A recent study showed testosterone as being an agonist of TRPM8, the predominant ion channel that contributes to cold hypersensitivity after injury. We investigated the effect of testosterone on cold sensitivity after nerve injury. Specifically, using the double plate test (DPT) (thermo-neutral-plate: 31 ºC and cold-plate: 18 ºC) we determined the thermal preference of mice at different points during the study design consisting of: orchiectomy, tibial nerve transection (TNT) (30 days after orchiectomy), 15-days-repeated subcutaneous injections of testosterone enanthate (250 or 500 µg/kg/day) or vehicle (started 12 h after TNT surgery). Different parameters such as time spent on cold plates, distance traveled, animal speed on the cold- and thermo-neutral-plates were determined in naïve, sham and neuropathic animals. Neither orchiectomy nor sham TNT surgery generate effects on cold intolerance and animal activity while TNT surgery decreased the time spent on the cold-plate and the distance traveled during DPT. Testosterone administration reversed the effect of nerve injury, decreasing the cold hypersensitivity and increasing activity of TNT mice. However, the effect of testosterone on cold avoidance reduced with time and at 14 days after TNT surgery, a higher dose was needed to reverse the effect generated by nerve injury. This indicates that although testosterone administration has a positive effect on cold intolerance, it might not be suitable for prolongated treatment. |
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| DOI: | doi:10.1016/j.bbr.2022.114269 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.bbr.2022.114269 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0166432822005381 |
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| | DOI: https://doi.org/10.1016/j.bbr.2022.114269 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cold allodynia |
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| | Double Plate Technique |
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| | Mice |
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| | Neuropathic pain |
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| | Testosterone |
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| K10plus-PPN: | 1902989473 |
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| Verknüpfungen: | → Zeitschrift |
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Reversal of cold intolerance by testosterone in orchiectomized mice after tibial nerve transection / Khalilzadeh, Emad [VerfasserIn]; 12 March 2023 (Online-Ressource)
