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| Verfasst von: | Theisen, Benjamin [VerfasserIn]  |
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| | Lichtenstern, Christoph [VerfasserIn] |
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| | Nußhag, Christian [VerfasserIn] |
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| | Tan, Benjamin [VerfasserIn] |
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| | Hölle, Tobias [VerfasserIn] |
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| | Weigand, Markus A. [VerfasserIn] |
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| | Kalenka, Armin [VerfasserIn] |
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| | Fiedler-Kalenka, Mascha [VerfasserIn] |
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| Titel: | Simultaneous removal of endotoxins, inflammatory mediators and uremic toxins in ICU patients with septic shock |
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| Titelzusatz: | a retrospective cohort study |
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| Verf.angabe: | Benjamin E. Theisen, Christoph Lichtenstern, Christian Nusshag, Benjamin Tan, Tobias Hölle, Markus A. Weigand, Armin Kalenka & Mascha O. Fiedler-Kalenka |
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| E-Jahr: | 2024 |
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| Jahr: | 23 August 2024 |
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| Umfang: | 15 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 19.09.2024 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 14(2024), Artikel-ID 19645, Seite 1-15 |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Sepsis, one of the leading causes of death, is still lacking specific treatment. OXIRIS (BAXTER, Deerfield, IL, USA) is the first device allowing combined removal of endotoxins, inflammatory mediators and uremic toxins, alongside fluid balance control. Available data is very limited. This retrospective propensity score-matched cohort study of adult patients with septic shock aimed to evaluate septic shock duration and mortality in patients treated with either standard of care renal replacement therapy (RRT) or RRT with combined hemoadsorption, who were admitted to the interdisciplinary surgical intensive care unit at Heidelberg University Hospital during the years 2018 through 2021. Main outcomes were duration of shock, thirty-day mortality and plasma interleukin-6 levels before and after initiation of hemoadsorption. Included were 117 patients (female, 33%; male 67%); median age: 67 (16) years. After matching: 42 patients (female, 33%; male, 67%); mean age: 59.1 ± 13.8 years. There was no statistically significant difference in septic shock duration (p = 0.94; hazard ratio (HR) 0.97 (95% CI, 0.48-1.97)). Thirty-day survival analysis showed a non-statistically significant survival difference. (p = 0.063; HR 0.43 (95% CI, 0.17-1.09)). A post-hoc 90-day survival analysis revealed statistically significant longer survival and lower death hazard ratio in patients treated with RRT + HA (p = 0.037; HR = 0.42 (95% CI, 0.18-0.99). In conclusion, RRT with combined hemoadsorption of endotoxins, inflammatory mediators and uremic toxins is a modality worth further investigation. |
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| DOI: | doi:10.1038/s41598-024-70522-3 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41598-024-70522-3 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41598-024-70522-3 |
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| | DOI: https://doi.org/10.1038/s41598-024-70522-3 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bacterial infection |
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| | Cardiovascular diseases |
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| | Health care |
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| | Immunological disorders |
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| | Infectious diseases |
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| | Kidney diseases |
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| | Renal replacement therapy |
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| K10plus-PPN: | 1903000351 |
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| Verknüpfungen: | → Zeitschrift |
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Simultaneous removal of endotoxins, inflammatory mediators and uremic toxins in ICU patients with septic shock / Theisen, Benjamin [VerfasserIn]; 23 August 2024 (Online-Ressource)
