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| Verfasst von: | Kliewe, Felix [VerfasserIn]  |
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| | Siegerist, Florian [VerfasserIn] |
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| | Hammer, Elke [VerfasserIn] |
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| | Al-Hasani, Jaafar [VerfasserIn] |
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| | Amling, Theodor Rolf Jakob [VerfasserIn] |
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| | Hollemann, Jonas Zeno Eddy [VerfasserIn] |
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| | Schindler, Maximilian [VerfasserIn] |
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| | Drenic, Vedran [VerfasserIn] |
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| | Simm, Stefan [VerfasserIn] |
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| | Amann, Kerstin [VerfasserIn] |
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| | Daniel, Christoph [VerfasserIn] |
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| | Lindenmeyer, Maja [VerfasserIn] |
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| | Hecker, Markus [VerfasserIn] |
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| | Völker, Uwe [VerfasserIn] |
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| | Endlich, Nicole [VerfasserIn] |
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| Titel: | Zyxin is important for the stability and function of podocytes, especially during mechanical stretch |
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| Verf.angabe: | Felix Kliewe, Florian Siegerist, Elke Hammer, Jaafar Al-Hasani, Theodor Rolf Jakob Amling, Jonas Zeno Eddy Hollemann, Maximilian Schindler, Vedran Drenic, Stefan Simm, Kerstin Amann, Christoph Daniel, Maja Lindenmeyer, Markus Hecker, Uwe Völker & Nicole Endlich |
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| Jahr: | 2024 |
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| Umfang: | 14 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Online veröffentlicht: 11. April 2024 ; Gesehen am 19.09.2024 |
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| Titel Quelle: | Enthalten in: Communications biology |
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| Ort Quelle: | London : Springer Nature, 2018 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 7(2024), Artikel-ID 446, Seite 1-14 |
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| ISSN Quelle: | 2399-3642 |
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| Abstract: | Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for podocyte stability and function. We have found that zyxin is significantly up-regulated in podocytes after mechanical stretch and relocalizes from focal adhesions to actin filaments. In zyxin knockout podocytes, we found that the loss of zyxin reduced the expression of vinculin and VASP as well as the expression of matrix proteins, such as fibronectin. This suggests that zyxin is a central player in the translation of mechanical forces in podocytes. In vivo, zyxin is highly up-regulated in patients suffering from diabetic nephropathy and in hypertensive DOCA-salt treated mice. Furthermore, zyxin loss in mice resulted in proteinuria and effacement of podocyte foot processes that was measured by super resolution microscopy. This highlights the essential role of zyxin for podocyte maintenance in vitro and in vivo, especially under mechanical stretch. |
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| DOI: | doi:10.1038/s42003-024-06125-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s42003-024-06125-5 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s42003-024-06125-5 |
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| | DOI: https://doi.org/10.1038/s42003-024-06125-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cell biology |
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| | Cytoskeleton |
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| | Kidney |
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| | Kidney diseases |
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| | Mechanisms of disease |
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| K10plus-PPN: | 1903024579 |
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| Verknüpfungen: | → Zeitschrift |
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Zyxin is important for the stability and function of podocytes, especially during mechanical stretch / Kliewe, Felix [VerfasserIn]; 2024 (Online-Ressource)
