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Verfasst von:Buhl, Rebecca [VerfasserIn]   i
 Yildirim, Timur Mert [VerfasserIn]   i
 Schickhardt, Sonja [VerfasserIn]   i
 Britz, Leoni [VerfasserIn]   i
 Lieberwirth, Ingo [VerfasserIn]   i
 Auffarth, Gerd U. [VerfasserIn]   i
 Khoramnia, Ramin [VerfasserIn]   i
Titel:Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcification
Verf.angabe:Rebecca Buhl, Timur Mert Yildirim, Sonja Katrin Schickhardt, Leoni Britz, Ingo Lieberwirth, Gerd Uwe Auffarth and Ramin Khoramnia
E-Jahr:2024
Jahr:23 August 2024
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 20.09.2024
Titel Quelle:Enthalten in: BMC ophthalmology
Ort Quelle:London : BioMed Central, 2001
Jahr Quelle:2024
Band/Heft Quelle:24(2024), Artikel-ID 363, Seite 1-12
ISSN Quelle:1471-2415
Abstract:Background: Clinical evidence suggests an association between phosphate concentrations in aqueous humor and the risk of intraocular lens (IOL) calcification. To test this hypothesis the influence of different phosphate concentrations on IOL calcification was evaluated in an in vitro electrophoresis model. Methods: 20 IOLs of two hydrophilic IOL models (CT Spheris 204, Zeiss; Lentis L-313, Oculentis) and one hydrophobic control IOL model (Clareon CNA0T0, Alcon) were exposed to physiologic and elevated phosphate concentrations, similar to diabetic aqueous humor. IOL calcification was analyzed by alizarin red staining, von Kossa staining, scanning electron microscopy, energy dispersive x-ray spectroscopy and transmission electron microscopy with electron diffraction. Results: Higher phosphate concentrations were associated with IOL calcification. Analyses of IOL surfaces and cross-sections documented calcification in no CT Spheris and 4 Lentis IOLs following exposure to 10 mM Na2HPO4, compared with 7 and 11 positive analyses following exposure to 14 mM Na2HPO4, respectively. Furthermore, a clear association between IOL calcification and the duration of electrophoresis was demonstrated, confirming increased phosphate concentrations and duration of exposure as risk factors of IOL calcification. Conclusions: Findings suggest that higher phosphate concentrations in aqueous humor, as seen in diabetic patients, contribute to an increased IOL calcification risk, potentially explaining clinical observations showing an increased risk of IOL calcification in patients with diabetes.
DOI:doi:10.1186/s12886-024-03553-z
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1186/s12886-024-03553-z
 DOI: https://doi.org/10.1186/s12886-024-03553-z
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aqueous humor
 Diabetes
 IOL Calcification
 Phosphate concentration
 Proliferative diabetic retinopathy
K10plus-PPN:1903056055
Verknüpfungen:→ Zeitschrift

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