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Verfasst von:Göbel, Verena [VerfasserIn]   i
 Hoffmann, Hans-Georg [VerfasserIn]   i
 Müller-Wiefel, Dirk E. [VerfasserIn]   i
 Braun, Andrea [VerfasserIn]   i
 Ludwig, Rolf [VerfasserIn]   i
 Schärer, Karl [VerfasserIn]   i
 Debatin, Klaus-Michael [VerfasserIn]   i
Titel:Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin
Verf.angabe:Verena Göbel, Hans-Georg Hoffmann, Dirk E. Müller-Wiefel, Andrea Braun, Rolf Ludwig, Karl Schärer, Klaus-Michael Debatin
E-Jahr:1994
Jahr: January 1994
Umfang:6 S.
Fussnoten:Gesehen am 24.09.2024
Titel Quelle:Enthalten in: European journal of pediatrics
Ort Quelle:Berlin : Springer Science & Business Media B.V., 1975
Jahr Quelle:1994
Band/Heft Quelle:153(1994), 1, Seite 43-48
ISSN Quelle:1432-1076
Abstract:The effect of recombinant human erythropoietin (rhEPO) and interleukin 3 (IL3) on circulating haematopoietic progenitors consisting mainly of immature burst-forming-units-erythrocytes (BFU-E), was investigated in ten paediatric patients treated by regular haemodialysis. During a 30-week study rhEPO treatment resulted in a rise of median haemoglobin levels from 6.7 g/dl to >10 g/dl in all patients. Before initiating rhEPO treatment the number of circulating BFU-E in chronic renal failure patients responded to grading doses of rhEPO in vitro similar to that in control children; however, the dose-response curves were not predictive for the in vivo response to rhEPO. After an initial rise in five patients BFU-E numbers declined by week 30 of rhEPO treatment. BFU-E numbers decreased to 35% of pretreatment values. The number of granulocyte-macrophage colony forming cells (GM-CFC) also decreased during rhEPO treatment. Addition of IL3 to the culture medium containing saturating concentrations of granulocyte-macrophage colony stimulating factor did not stimulate BFU-E numbers of patients before rhEPO treatment or those of controls. However, 2 weeks after start of rhEPO treatment IL3 increased the growth of patient's BFU-E in vitro to 220% of pretreatment levels, followed by a gradual decrease of stimulation until the end of observation. These findings indicate that: (1) long-term recruitment of circulating haematopoietic progenitors during rhEPO treatment is low in children with renal anaemia; (2) rhEPO sensitivity of circulating BFU-E is not predictive for the in vivo response; (3) rhEPO treatment results in enhanced sensitivity of BFU-E to IL3.
DOI:doi:10.1007/BF02000786
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/BF02000786
 DOI: https://doi.org/10.1007/BF02000786
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chronic renal failure Erythropoietin
 Haematopoietic progenitors
 Haemodialysis Interleukin 3
K10plus-PPN:1903357470
Verknüpfungen:→ Zeitschrift

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