| Online-Ressource |
Verfasst von: | Göbel, Verena [VerfasserIn]  |
| Hoffmann, Hans-Georg [VerfasserIn]  |
| Müller-Wiefel, Dirk E. [VerfasserIn]  |
| Braun, Andrea [VerfasserIn]  |
| Ludwig, Rolf [VerfasserIn]  |
| Schärer, Karl [VerfasserIn]  |
| Debatin, Klaus-Michael [VerfasserIn]  |
Titel: | Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin |
Verf.angabe: | Verena Göbel, Hans-Georg Hoffmann, Dirk E. Müller-Wiefel, Andrea Braun, Rolf Ludwig, Karl Schärer, Klaus-Michael Debatin |
E-Jahr: | 1994 |
Jahr: | January 1994 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 24.09.2024 |
Titel Quelle: | Enthalten in: European journal of pediatrics |
Ort Quelle: | Berlin : Springer Science & Business Media B.V., 1975 |
Jahr Quelle: | 1994 |
Band/Heft Quelle: | 153(1994), 1, Seite 43-48 |
ISSN Quelle: | 1432-1076 |
Abstract: | The effect of recombinant human erythropoietin (rhEPO) and interleukin 3 (IL3) on circulating haematopoietic progenitors consisting mainly of immature burst-forming-units-erythrocytes (BFU-E), was investigated in ten paediatric patients treated by regular haemodialysis. During a 30-week study rhEPO treatment resulted in a rise of median haemoglobin levels from 6.7 g/dl to >10 g/dl in all patients. Before initiating rhEPO treatment the number of circulating BFU-E in chronic renal failure patients responded to grading doses of rhEPO in vitro similar to that in control children; however, the dose-response curves were not predictive for the in vivo response to rhEPO. After an initial rise in five patients BFU-E numbers declined by week 30 of rhEPO treatment. BFU-E numbers decreased to 35% of pretreatment values. The number of granulocyte-macrophage colony forming cells (GM-CFC) also decreased during rhEPO treatment. Addition of IL3 to the culture medium containing saturating concentrations of granulocyte-macrophage colony stimulating factor did not stimulate BFU-E numbers of patients before rhEPO treatment or those of controls. However, 2 weeks after start of rhEPO treatment IL3 increased the growth of patient's BFU-E in vitro to 220% of pretreatment levels, followed by a gradual decrease of stimulation until the end of observation. These findings indicate that: (1) long-term recruitment of circulating haematopoietic progenitors during rhEPO treatment is low in children with renal anaemia; (2) rhEPO sensitivity of circulating BFU-E is not predictive for the in vivo response; (3) rhEPO treatment results in enhanced sensitivity of BFU-E to IL3. |
DOI: | doi:10.1007/BF02000786 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/BF02000786 |
| DOI: https://doi.org/10.1007/BF02000786 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Chronic renal failure Erythropoietin |
| Haematopoietic progenitors |
| Haemodialysis Interleukin 3 |
K10plus-PPN: | 1903357470 |
Verknüpfungen: | → Zeitschrift |
Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin / Göbel, Verena [VerfasserIn]; January 1994 (Online-Ressource)