Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children

• Verfasst von: Bäumler, Caroline Beatrix [VerfasserIn]
• Verfasst von: Bonier, Thomas [VerfasserIn]
• Verfasst von: Herr, Ingrid [VerfasserIn]
• Verfasst von: Benner, Axel [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Verfasst von: Debatin, Klaus-Michael [VerfasserIn]
• Titel: Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children
• Verf.angabe: Caroline B. Bäumler, Thomas Bonier, Ingrid Herr, Axel Benner, Peter H. Krammer, Klaus-Michael Debatin
• E-Jahr: 1996
• Jahr: 1 September 1996
• Umfang: 6 S.
• Fussnoten: Elektronische Reproduktion der Druck-Ausgabe 14. Dezember 2020 ; Gesehen am 24.09.2024
• Titel Quelle: Enthalten in: Blood
• Ort Quelle: Washington, DC : American Society of Hematology, 1946
• Jahr Quelle: 1996
• Band/Heft Quelle: 88(1996), 5, Seite 1741-1746
• ISSN Quelle: 1528-0020
• DOI: doi:10.1182/blood.V88.5.1741.1741
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1903378818

Abstract

Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)-infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in T cells of HIV-1-infected children. In this report we provide further evidence for a deregulated CD95 system in AIDS. CD95 expression in HIV-1+ children is not restricted to previously activated CD45RO+ T cells but is also increased on freshly isolated naive CD45RA+ T cells. In addition, specific CD95-mediated apoptosis is enhanced in both CD4+ and CD8+ T cells. Furthermore, levels of CD95 ligand mRNA are profoundly increased. Specific T-cell receptor/CD3-triggered apoptosis in HIV-1+ children is more enhanced in CD8+ than in CD4+ T cells. Accelerated activation induced cell death of T cells could partially be inhibited by blocking anti-CD95 antibody fragments. These data suggest an involvement of the CD95 receptor/ligand system in T-cell depletion and apoptosis in AIDS and may open new avenues of rational intervention strategies.