Quality-of-life outcomes of the ROBOtic-assisted versus Conventional Open Partial nephrectomy (ROBOCOP) II trial

• Verfasst von: Sidoti Abate, Marie Angela [VerfasserIn]
• Verfasst von: Menold, Hanna [VerfasserIn]
• Verfasst von: Neuberger, Manuel [VerfasserIn]
• Verfasst von: Kirchner, Marietta [VerfasserIn]
• Verfasst von: Haney, Caelán Max [VerfasserIn]
• Verfasst von: Nuhn, Philipp [VerfasserIn]
• Verfasst von: Westhoff, Niklas Christian [VerfasserIn]
• Verfasst von: Honeck, Patrick [VerfasserIn]
• Verfasst von: Michel, Maurice Stephan [VerfasserIn]
• Verfasst von: Kriegmair, Maximilian [VerfasserIn]
• Verfasst von: Kowalewski, Karl-Friedrich [VerfasserIn]
• Titel: Quality-of-life outcomes of the ROBOtic-assisted versus Conventional Open Partial nephrectomy (ROBOCOP) II trial
• Verf.angabe: Marie Angela Sidoti Abate, Hanna Saskia Menold, Manuel Neuberger, Marietta Kirchner, Caelan Max Haney, Philipp Nuhn, Niklas Westhoff, Patrick Honeck, Maurice-Stephan Michel, Maximilian Christian Kriegmair and Karl-Friedrich Kowalewski
• E-Jahr: 2024
• Jahr: September 2024
• Umfang: 8 S.
• Illustrationen: Illustrationen
• Fussnoten: Zuerst veröffentlicht: 24. Mai 2024 ; Gesehen am 26.09.2024
• Titel Quelle: Enthalten in: BJU international
• Ort Quelle: Oxford : Wiley-Blackwell, 1999
• Jahr Quelle: 2024
• Band/Heft Quelle: 134(2024), 3 vom: Sept., Seite 434-441
• ISSN Quelle: 1464-410X
• DOI: doi:10.1111/bju.16407
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Aged
• Sach-SW: evidence‐based medicine
• Sach-SW: Female
• Sach-SW: Humans
• Sach-SW: kidney cancer
• Sach-SW: Kidney Neoplasms
• Sach-SW: Male
• Sach-SW: Middle Aged
• Sach-SW: Nephrectomy
• Sach-SW: Pain, Postoperative
• Sach-SW: partial nephrectomy
• Sach-SW: quality of life
• Sach-SW: Quality of Life
• Sach-SW: randomised controlled trial
• Sach-SW: robot‐assisted‐surgery
• Sach-SW: Robotic Surgical Procedures
• Sach-SW: Treatment Outcome
• K10plus-PPN: 190355747X

Abstract

OBJECTIVES: To comprehensively compare quality-of-life (QoL) outcomes between open partial nephrectomy (OPN) and robot-assisted PN (RAPN) from the randomised ROBOtic-assisted versus Conventional Open Partial nephrectomy (ROBOCOP) II trial, as QoL data comparing OPN and RAPN are virtually non-existent, especially not from randomised controlled trials (RCTs). PATIENTS AND METHODS: The ROBOCOP II was a single-centre, open-label RCT between OPN and RAPN. The pre-planned analyses of QoL outcomes are presented. Data were analysed descriptively in a modified intention-to-treat population. RESULTS: A total of 50 patients underwent surgery. At postoperative Day 90 (POD90), there was no significant difference for the Kidney Disease Quality of Life-Short Form questionnaire score (mean [sd] OPN 72 [20] vs RAPN 76 [15], P = 0.850), while there were advantages for RAPN in the subdomains of 'Pain' (P = 0.006) and 'Physical functioning' (P = 0.011) immediately after surgery. For the European Organisation for Research and Treatment of Cancer quality of life questionnaire 30-item core there were overall advantages directly after surgery (mean [sd] score OPN 63 [20] vs RAPN 75 [17], P = 0.031), as well as for the subdomains 'Fatigue' (P = 0.026), 'Pain' (P = 0.002) and 'Constipation' (P = 0.045) but no differences at POD90. There were no differences for the EuroQoL five Dimensions five Levels questionnaire at POD90 (mean [sd] score OPN 70 [22] vs RAPN 72 [17], P = 1.0) or at any other time point. Finally, no significant differences were found for the overall Convalescence and Recovery Evaluation questionnaire score at POD90 (mean [sd] OPN 84 [13] vs RAPN 86 [10], P = 0.818) but less pain in the RAPN group (P = 0.017) directly after surgery. CONCLUSIONS: Pain and physical functioning as subdomains of QoL are improved after RAPN compared to OPN in the early postoperative course, while there are no differences anymore after 3 months.