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Verfasst von:Monavari, Mahshid [VerfasserIn]   i
 Sohrabi, Razieh [VerfasserIn]   i
 Motasadizadeh, Hamidreza [VerfasserIn]   i
 Monavari, Mehran [VerfasserIn]   i
 Fatahi, Yousef [VerfasserIn]   i
 Ejarestaghi, Negin Mousavi [VerfasserIn]   i
 Fuentes-Chandia, Miguel [VerfasserIn]   i
 Leal-Egaña, Aldo [VerfasserIn]   i
 Akrami, Mohammad [VerfasserIn]   i
 Homaeigohar, Shahin [VerfasserIn]   i
Titel:Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing
Verf.angabe:Mahshid Monavari, Razieh Sohrabi, Hamidreza Motasadizadeh, Mehran Monavari, Yousef Fatahi, Negin Mousavi Ejarestaghi, Miguel Fuentes-Chandia, Aldo Leal-Egaña, Mohammad Akrami and Shahin Homaeigohar
E-Jahr:2024
Jahr:28 March 2024
Umfang:14 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 27.09.2024
Titel Quelle:Enthalten in: Frontiers in Bioengineering and Biotechnology
Ort Quelle:Lausanne : Frontiers Media, 2013
Jahr Quelle:2024
Band/Heft Quelle:12(2024), Artikel-ID 1352717, Seite 1-14
ISSN Quelle:2296-4185
Abstract:This study developed a new burn wound dressing based on core-shell nanofibers that co-deliver antibiotic and antioxidant drugs. For this purpose, poly(ethylene oxide) (PEO)-chitosan (CS)/poly(D,L-lactide-co-glycolide) (PLGA) core-shell nanofibers were fabricated through co-axial electrospinning technique. Antibiotic levofloxacin (LEV) and antioxidant quercetin (QS) were incorporated into the core and shell parts of PEO-CS/PLGA nanofibers, respectively. The drugs could bond to the polymer chains through hydrogen bonding, leading to their steady release for 168 h. An in vitro drug release study showed a burst effect followed by sustained release of LEV and QS from the nanofibers due to the Fickian diffusion. The NIH 3T3 fibroblast cell viability of the drug loaded core-shell nanofibers was comparable to that in the control (tissue culture polystyrene) implying biocompatibility of the nanofibers and their cell supportive role. However, there was no significant difference in cell viability between the drug loaded and drug free core-shell nanofibers. According to in vivo experiments, PEO-CS-LEV/PLGA-QS core-shell nanofibers could accelerate the healing process of a burn wound compared to a sterile gauze. Thanks to the synergistic therapeutic effect of LEV and QS, a significantly higher wound closure rate was recorded for the drug loaded core-shell nanofibrous dressing than the drug free nanofibers and control. Conclusively, PEO-CS-LEV/PLGA-QS core-shell nanofibers were shown to be a promising wound healing material that could drive the healing cascade through local co-delivery of LEV and QS to burn wounds.
DOI:doi:10.3389/fbioe.2024.1352717
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3389/fbioe.2024.1352717
 Volltext: https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1352717/full
 DOI: https://doi.org/10.3389/fbioe.2024.1352717
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Burn wound
 Co-axial electrospinning
 Core-shell nanofiber
 Drug delivery
 Wound Healing
K10plus-PPN:1903706750
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