Impact of angiopoietin-2 on kidney diseases

• Verfasst von: Li, Mei [VerfasserIn]
• Verfasst von: Popovic, Zoran V. [VerfasserIn]
• Verfasst von: Chu, Chang [VerfasserIn]
• Verfasst von: Reichetzeder, Christoph [VerfasserIn]
• Verfasst von: Pommer, Wolfgang [VerfasserIn]
• Verfasst von: Krämer, Bernhard [VerfasserIn]
• Verfasst von: Hocher, Berthold [VerfasserIn]
• Titel: Impact of angiopoietin-2 on kidney diseases
• Verf.angabe: Mei Li, Zoran Popovic, Chang Chu, Christoph Reichetzeder, Wolfgang Pommer, Bernhard K. Krämer, Berthold Hocher
• E-Jahr: 2023
• Jahr: May 2023
• Umfang: 14 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 14. März 2023 ; Gesehen am 30.09.2024
• Titel Quelle: Enthalten in: Kidney diseases
• Ort Quelle: Basel : Karger, 2015
• Jahr Quelle: 2023
• Band/Heft Quelle: 9(2023), 3, Seite 143-156
• ISSN Quelle: 2296-9357
• DOI: doi:10.1159/000529774
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1903737559

Abstract

Background: Angiopoietins (Ang) are essential angiogenic factors involved in angiogenesis, vascular maturation, and inflammation. The most studied angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), behave antagonistically to each other in vivo to sustain vascular endothelium homeostasis. While Ang-1 typically acts as the endothelium-protective mediator, its context-dependent antagonist Ang-2 can promote endothelium permeability and vascular destabilization, hence contributing to a poor outcome in vascular diseases via endothelial injury, vascular dysfunction, and microinflammation. The pathogenesis of kidney diseases is associated with endothelial dysfunction and chronic inflammation in renal diseases. Summary: Several preclinical studies report overexpression of Ang-2 in renal tissues of certain kidney disease models; additionally, clinical studies show increased levels of circulating Ang-2 in the course of chronic kidney disease, implying that Ang-2 may serve as a useful biomarker in these patients. However, the exact mechanisms of Ang-2 action in renal diseases remain unclear. Key Messages: We summarized the recent findings on Ang-2 in kidney diseases, including preclinical studies and clinical studies, aiming to provide a systematic understanding of the role of Ang-2 in these diseases.