Stress-induced sensitization of insula activation predicts alcohol craving and alcohol use in alcohol use disorder

• Verfasst von: Bach, Patrick [VerfasserIn]
• Verfasst von: Zaiser, Judith [VerfasserIn]
• Verfasst von: Vetter, Sina [VerfasserIn]
• Verfasst von: Gessner, Tatjana [VerfasserIn]
• Verfasst von: Hoffmann, Sabine [VerfasserIn]
• Verfasst von: Gerhardt, Sarah [VerfasserIn]
• Verfasst von: Berhe, Oksana [VerfasserIn]
• Verfasst von: Bekier, Nina Kim [VerfasserIn]
• Verfasst von: Abel, Martin [VerfasserIn]
• Verfasst von: Radler, Philipp [VerfasserIn]
• Verfasst von: Langejürgen, Jens [VerfasserIn]
• Verfasst von: Tost, Heike [VerfasserIn]
• Verfasst von: Lenz, Bernd [VerfasserIn]
• Verfasst von: Vollstädt-Klein, Sabine [VerfasserIn]
• Verfasst von: Stallkamp, Jan [VerfasserIn]
• Verfasst von: Kirschbaum, Clemens [VerfasserIn]
• Verfasst von: Kiefer, Falk [VerfasserIn]
• Titel: Stress-induced sensitization of insula activation predicts alcohol craving and alcohol use in alcohol use disorder
• Titelzusatz: archival report
• Verf.angabe: Patrick Bach, Judith Zaiser, Sina Zimmermann, Tatjana Gessner, Sabine Hoffmann, Sarah Gerhardt, Oksana Berhe, Nina Kim Bekier, Martin Abel, Philipp Radler, Jens Langejürgen, Heike Tost, Bernd Lenz, Sabine Vollstädt-Klein, Jan Stallkamp, Clemens Kirschbaum, and Falk Kiefer
• E-Jahr: 2024
• Jahr: 1 February 2024
• Umfang: 11 S.
• Fussnoten: Online verfügbar: 9. September 2023, Artikelversion: 22. December 2023 ; Gesehen am 01.10.2024
• Titel Quelle: Enthalten in: Biological psychiatry
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1985
• Jahr Quelle: 2024
• Band/Heft Quelle: 95(2024), 3 vom: Feb., Seite 245-255
• ISSN Quelle: 1873-2402
• DOI: doi:10.1016/j.biopsych.2023.08.024
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Alcohol use disorder
• Sach-SW: Cortisol
• Sach-SW: Craving
• Sach-SW: Cue reactivity
• Sach-SW: fMRI
• Sach-SW: Stress
• K10plus-PPN: 1903834074

Abstract

Background - Stress and alcohol cues trigger alcohol consumption and relapse in alcohol use disorder. However, the neurobiological processes underlying their interaction are not well understood. Thus, we conducted a randomized, controlled neuroimaging study to investigate the effects of psychosocial stress on neural cue reactivity and addictive behaviors. - Methods - Neural alcohol cue reactivity was assessed in 91 individuals with alcohol use disorder using a validated functional magnetic resonance imaging (fMRI) task. Activation patterns were measured twice, at baseline and during a second fMRI session, prior to which participants were assigned to psychosocial stress (experimental condition) or a matched control condition or physical exercise (control conditions). Together with fMRI data, alcohol craving and cortisol levels were assessed, and alcohol use data were collected during a 12-month follow-up. Analyses tested the effects of psychosocial stress on neural cue reactivity and associations with cortisol levels, craving, and alcohol use. - Results - Compared with both control conditions, psychosocial stress elicited higher alcohol cue-induced activation in the left anterior insula (familywise error-corrected p < .05) and a stress- and cue-specific dynamic increase in insula activation over time (F22,968 = 2.143, p = .007), which was predicted by higher cortisol levels during the experimental intervention (r = 0.310, false discovery rate-corrected p = .016). Cue-induced insula activation was positively correlated with alcohol craving during fMRI (r = 0.262, false discovery rate-corrected p = .032) and alcohol use during follow-up (r = 0.218, false discovery rate-corrected p = .046). - Conclusions - Results indicate a stress-induced sensitization of cue-induced activation in the left insula as a neurobiological correlate of the effects of psychosocial stress on alcohol craving and alcohol use in alcohol use disorder, which likely reflects changes in salience attribution and goal-directed behavior.