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Verfasst von:Heidenreich, Daniela [VerfasserIn]   i
 Kreil, Sebastian [VerfasserIn]   i
 Müller, Nadine Zoé [VerfasserIn]   i
 Jawhar, Mohamad [VerfasserIn]   i
 Nolte, Florian [VerfasserIn]   i
 Hofmann, Wolf-Karsten [VerfasserIn]   i
 Klein, Stefan [VerfasserIn]   i
Titel:Topical treatment of acyclovir-resistant herpes simplex virus stomatitis after allogeneic hematopoietic cell transplantation
Verf.angabe:Daniela Heidenreich, Sebastian Kreil, Nadine Mueller, Mohamad Jawhar, Florian Nolte, Wolf-Karsten Hofmann, Stefan A. Klein
E-Jahr:2020
Jahr:October 16, 2020
Umfang:6 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 01.10.2024
Titel Quelle:Enthalten in: Oncology research and treatment
Ort Quelle:Basel : Karger, 2014
Jahr Quelle:2020
Band/Heft Quelle:43(2020), 12 vom: Dez., Seite 672-677
ISSN Quelle:2296-5262
Abstract:Introduction: We report on patients who developed severe acyclovir-resistant (ACVr) herpes simplex virus 1 (HSV-1) stomatitis after allogeneic hematopoietic cell transplantation (HCT). Patients: HCT patients suffering from HSV-1 stomatitis without response after 1 week of high-dose acyclovir (ACV) were tested for ACV resistance. Patients with proven ACV resistance were treated either topically with cidofovir solution and gel or with topical foscavir cream or with intravenous foscavir. Results: Among 214 consecutive HCT patients, 6 developed severe ACVr HSV-1 stomatitis (WHO grade III n = 1, WHO grade IV n = 5). All 6 patients suffered from relapse of acute myeloid leukemia (AML) after HCT. ACVr stomatitis was treated topically with first-line (n = 4) or second-line (n = 2) cidofovir. Topical foscavir cream was applied as first-line (n = 1) or second-line (n = 1) therapy. Intravenous foscavir was used in 3 patients (first-line therapy, n = 1; second-line therapy, n = 2). Complete remission was reached by topical cidofovir (n = 3), topical foscavir (n = 1), and intravenous foscavir (n = 1), respectively. Five of the 6 patients died due to progression of leukemia. Only 1 patient survived. Conclusions: ACVr HSV-1 stomatitis is a severe complication in AML patients relapsing after HCT. It reflects the seriously impaired general condition of these patients. This analysis shows that topical treatment with cidofovir or foscavir might be a sufficient first-line therapy approach in ACVr HSV-1 stomatitis. It might serve as a less toxic alternative to intravenous foscavir.
DOI:doi:10.1159/000510988
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000510988
 Volltext: https://karger.com/ort/article/43/12/672/263675/Topical-Treatment-of-Acyclovir-Resistant-Herpes
 DOI: https://doi.org/10.1159/000510988
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1903850193
Verknüpfungen:→ Zeitschrift

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