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Verfasst von:Cattarinussi, Giulia [VerfasserIn]   i
 Gugliotta, Alessio A. [VerfasserIn]   i
 Hirjak, Dusan [VerfasserIn]   i
 Wolf, Robert Christian [VerfasserIn]   i
 Sambataro, Fabio [VerfasserIn]   i
Titel:Brain mechanisms underlying catatonia
Titelzusatz:a systematic review
Verf.angabe:Giulia Cattarinussi, Alessio A. Gugliotta, Dusan Hirjak, Robert C. Wolf, Fabio Sambataro
E-Jahr:2024
Jahr:January 2024
Umfang:14 S.
Fussnoten:Online verfügbar: 18. November 2022, Artikelversion: 18. Dezember 2023 ; Gesehen am 01.10.2024
Weitere Titel:Titel des übergeordneten Special issue: Catatonia
Titel Quelle:Enthalten in: Schizophrenia research
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1988
Jahr Quelle:2024
Band/Heft Quelle:263(2024), Special issue vom: Jan., Seite 194-207
ISSN Quelle:1573-2509
Abstract:Background - Catatonia is a complex psychomotor disorder characterized by motor, affective, and behavioral symptoms. Despite being known for almost 150 years, its pathomechanisms are still largely unknown. - Methods - A systematic research on PubMed, Web of Science, and Scopus was conducted to identify neuroimaging studies conducted on group or single individuals with catatonia. Overall, 33 studies employing structural magnetic resonance imaging (sMRI, n = 11), functional magnetic resonance imaging (fMRI, n = 10), sMRI and fMRI (n = 2), functional near-infrared spectroscopy (fNIRS, n = 1), single positron emission computer tomography (SPECT, n = 4), positron emission tomography (PET, n = 4), and magnetic resonance spectroscopy (MRS, n = 1), and 171 case reports were retrieved. - Results - Observational sMRI studies showed numerous brain changes in catatonia, including diffuse atrophy and signal hyperintensities, while case-control studies reported alterations in fronto-parietal and limbic regions, the thalamus, and the striatum. Task-based and resting-state fMRI studies found abnormalities located primarily in the orbitofrontal, medial prefrontal, motor cortices, cerebellum, and brainstem. Lastly, metabolic and perfusion changes were observed in the basal ganglia, prefrontal, and motor areas. Most of the case-report studies described widespread white matter lesions and frontal, temporal, or basal ganglia hypoperfusion. - Conclusions - Catatonia is characterized by structural, functional, perfusion, and metabolic cortico-subcortical abnormalities. However, the majority of studies and case reports included in this systematic review are affected by considerable heterogeneity, both in terms of populations and neuroimaging techniques, which calls for a cautious interpretation. Further elucidation, through future neuroimaging research, could have great potential to improve the description of the neural motor and psychomotor mechanisms underlying catatonia.
DOI:doi:10.1016/j.schres.2022.11.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.schres.2022.11.002
 Volltext: https://www.sciencedirect.com/science/article/pii/S0920996422004078
 DOI: https://doi.org/10.1016/j.schres.2022.11.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Catatonia
 Functional magnetic resonance imaging
 Schizophrenia
 Structural magnetic resonance imaging
 Stupor
K10plus-PPN:1903870445
Verknüpfungen:→ Zeitschrift

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