| |  Online-Ressource |
|---|
| Verfasst von: | Körholz, Julia Christine [VerfasserIn]  |
|---|
| | Chen, Lan-Sun [VerfasserIn] |
|---|
| | Strauß, Timmy [VerfasserIn] |
|---|
| | Schuetz, Catharina [VerfasserIn] |
|---|
| | Dalpke, Alexander [VerfasserIn] |
|---|
| Titel: | One gene to rule them all |
|---|
| Titelzusatz: | clinical perspectives of a potent suppressor of cytokine signaling : SOCS1 |
|---|
| Verf.angabe: | Julia Körholz, Lan-Sun Chen, Timmy Strauss, Catharina Schuetz and Alexander H. Dalpke |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | 22 April 2024 |
|---|
| Umfang: | 8 S. |
|---|
| Fussnoten: | Gesehen am 07.10.2024 |
|---|
| Titel Quelle: | Enthalten in: Frontiers in immunology |
|---|
| Ort Quelle: | Lausanne : Frontiers Media, 2010 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 15(2024), Artikel-ID 1385190, Seite 1385190-01-1385190-08 |
|---|
| ISSN Quelle: | 1664-3224 |
|---|
| Abstract: | The discovery of Suppressor of Cytokine Signaling 1 (SOCS1) in 1997 marked a significant milestone in understanding the regulation of Janus kinase/Signal transducer and activator of transcription (JAK/STAT) signaling pathways. Subsequent research deciphered its cellular functions, and recent insights into SOCS1 deficiencies in humans underscored its critical role in immune regulation. In humans, SOCS-haploinsufficiency (SOCS1-HI) presents a diverse clinical spectrum, encompassing autoimmune diseases, infection susceptibility, and cancer. Variability in disease manifestation, even within families sharing the same genetic variant, raises questions about clinical penetrance and the need for individualized treatments. Current therapeutic strategies include JAK inhibition, with promising results in controlling inflammation in SOCS1-HI patients. Hematopoietic stem cell transplantation and gene therapy emerge as promising avenues for curative treatments. The evolving landscape of SOCS1 research, emphasizes the need for a nuanced understanding of genetic variants and their functional consequences. |
|---|
| DOI: | doi:10.3389/fimmu.2024.1385190 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3389/fimmu.2024.1385190 |
|---|
| | Volltext: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1385190/full |
|---|
| | DOI: https://doi.org/10.3389/fimmu.2024.1385190 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | JAKinhibitors |
|---|
| | monogenic hyperinflammation |
|---|
| | multisystem immunedysregulation |
|---|
| | SOCS1 |
|---|
| | SOCS1-HI |
|---|
| | SOCS1-immunity |
|---|
| K10plus-PPN: | 1905012802 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
One gene to rule them all / Körholz, Julia Christine [VerfasserIn]; 22 April 2024 (Online-Ressource)
