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Verfasst von:Song, Yunhe [VerfasserIn]   i
 Li, Fei [VerfasserIn]   i
 Chong, Rachel S. [VerfasserIn]   i
 Wang, Wei [VerfasserIn]   i
 Ran, An Ran [VerfasserIn]   i
 Lin, Fengbin [VerfasserIn]   i
 Wang, Peiyuan [VerfasserIn]   i
 Wang, Zhenyu [VerfasserIn]   i
 Jiang, Jingwen [VerfasserIn]   i
 Kong, Kangjie [VerfasserIn]   i
 Jin, Ling [VerfasserIn]   i
 Chen, Meiling [VerfasserIn]   i
 Sun, Jian [VerfasserIn]   i
 Wang, Deming [VerfasserIn]   i
 Tham, Clement C. [VerfasserIn]   i
 Lam, Dennis S. C. [VerfasserIn]   i
 Zangwill, Linda M. [VerfasserIn]   i
 Weinreb, Robert N. [VerfasserIn]   i
 Aung, Tin [VerfasserIn]   i
 Jonas, Jost B. [VerfasserIn]   i
 Ohno-Matsui, Kyoko [VerfasserIn]   i
 Cheng, Ching-Yu [VerfasserIn]   i
 Bressler, Neil M. [VerfasserIn]   i
 Sun, Xiaodong [VerfasserIn]   i
 Cheung, Carol Y. [VerfasserIn]   i
 Chen, Shida [VerfasserIn]   i
 Zhang, Xiulan [VerfasserIn]   i
Titel:High myopia normative database of peripapillary retinal nerve fiber layer thickness to detect myopic glaucoma in a Chinese population
Verf.angabe:Yunhe Song, MD, PhD, Fei Li, MD, PhD, Rachel S. Chong, MD, PhD, Wei Wang, MD, PhD, An Ran Ran, MMed, PhD, Fengbin Lin, MD, PhD, Peiyuan Wang, MD, Zhenyu Wang, MD, Jingwen Jiang, MD, Kangjie Kong, MD, Ling Jin, MSc, Meiling Chen, MBBS, Jian Sun, MBBS, Deming Wang, MD, Clement C. Tham, FCOphthHK, Dennis S.C. Lam, MD, PhD, Linda M. Zangwill, PhD, Robert N. Weinreb, MD, Tin Aung, MD, PhD, Jost B. Jonas, MD, Kyoko Ohno-Matsui, MD, PhD, Ching-Yu Cheng, MD, PhD, Neil M. Bressler, MD, Xiaodong Sun, MD, PhD, Carol Y. Cheung, PhD, Shida Chen, MD, PhD, Xiulan Zhang, MD, PhD, for the Glaucoma Suspects with High Myopia Study Group
E-Jahr:2023
Jahr:December 2023
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 26. Juli 2023, Artikelversion: 17. November 2023 ; Gesehen am 08.10.2024
Titel Quelle:Enthalten in: Ophthalmology
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1978
Jahr Quelle:2023
Band/Heft Quelle:130(2023), 12, Seite 1279-1289
ISSN Quelle:1549-4713
Abstract:Purpose - To develop and validate the performance of a high myopia (HM)-specific normative database of peripapillary retinal nerve fiber layer (pRNFL) thickness in differentiating HM from highly myopic glaucoma (HMG). - Design - Cross-sectional multicenter study. - Participants - A total of 1367 Chinese participants (2325 eyes) with nonpathologic HM or HMG were included from 4 centers. After quality control, 1108 eyes from 694 participants with HM were included in the normative database; 459 eyes from 408 participants (323 eyes with HM and 136 eyes with HMG) and 322 eyes from 197 participants (131 eyes with HM and 191 eyes with HMG) were included in the internal and external validation sets, respectively. Only HMG eyes with an intraocular pressure > 21 mmHg were included. - Methods - The pRNFL thickness was measured with swept-source (SS) OCT. Four strategies of pRNFL-specified values were examined, including global and quadrantic pRNFL thickness below the lowest fifth or the lowest first percentile of the normative database. - Main Outcomes Measures - The accuracy, sensitivity, and specificity of the HM-specific normative database for detecting HMG. - Results - Setting the fifth percentile of the global pRNFL thickness as the threshold, using the HM-specific normative database, we achieved an accuracy of 0.93 (95% confidence interval [CI], 0.90-0.95) and 0.85 (95% CI, 0.81-0.89), and, using the first percentile as the threshold, we acheived an accuracy of 0.85 (95% CI, 0.81-0.88) and 0.70 (95% CI, 0.65-0.75) in detecting HMG in the internal and external validation sets, respectively. The fifth percentile of the global pRNFL thickness achieved high sensitivities of 0.75 (95% CI, 0.67-0.82) and 0.75 (95% CI, 0.68-0.81) and specificities of 1.00 (95% CI, 0.99-1.00) and 1.00 (95% CI, 0.97-1.00) in the internal and external validation datasets, respectively. Compared with the built-in database of the OCT device, the HM-specific normative database showed a higher sensitivity and specificity than the corresponding pRNFL thickness below the fifth or first percentile (P < 0.001 for all). - Conclusions - The HM-specific normative database is more capable of detecting HMG eyes than the SS OCT built-in database, which may be an effective tool for differential diagnosis between HMG and HM. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
DOI:doi:10.1016/j.ophtha.2023.07.022
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ophtha.2023.07.022
 Volltext: https://www.sciencedirect.com/science/article/pii/S0161642023005183
 DOI: https://doi.org/10.1016/j.ophtha.2023.07.022
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Glaucoma
 High myopia
 Normative database
 OCT
 Retinal nerve fiber layer
K10plus-PPN:1905052782
Verknüpfungen:→ Zeitschrift

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