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| Verfasst von: | Tai, Panpan [VerfasserIn]  |
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| | Chen, Xinyu [VerfasserIn] |
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| | Jia, Guihua [VerfasserIn] |
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| | Chen, Guanjun [VerfasserIn] |
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| | Gong, Lian [VerfasserIn] |
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| | Cheng, Yaxin [VerfasserIn] |
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| | Li, Zhuan [VerfasserIn] |
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| | Wang, Heng [VerfasserIn] |
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| | Chen, Aiyan [VerfasserIn] |
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| | Zhang, Ganghua [VerfasserIn] |
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| | Zhu, Yuxing [VerfasserIn] |
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| | Xiao, Mengqing [VerfasserIn] |
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| | Wang, Zhanwang [VerfasserIn] |
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| | Liu, Yunqing [VerfasserIn] |
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| | Shan, Dongyong [VerfasserIn] |
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| | He, Dong [VerfasserIn] |
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| | Li, Moying [VerfasserIn] |
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| | Zhan, Tianzuo [VerfasserIn] |
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| | Khan, Abbas [VerfasserIn] |
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| | Li, Xiaohui [VerfasserIn] |
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| | Zeng, Xiangxiang [VerfasserIn] |
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| | Li, Chaopeng [VerfasserIn] |
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| | Ouyang, Dongsheng [VerfasserIn] |
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| | Ai, Kelong [VerfasserIn] |
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| | Chen, Xuan [VerfasserIn] |
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| | Liu, Dongbo [VerfasserIn] |
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| | Liu, Zhonghua [VerfasserIn] |
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| | Wei, Dongqing [VerfasserIn] |
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| | Cao, Ke [VerfasserIn] |
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| Titel: | WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis |
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| Verf.angabe: | Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He, Moying Li, Tianzuo Zhan, Abbas Khan, Xiaohui Li, Xiangxiang Zeng, Chaopeng Li, Dongsheng Ouyang, Kelong Ai, Xuan Chen, Dongbo Liu, Zhonghua Liu, Dongqing Wei and Ke Cao |
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| E-Jahr: | 2023 |
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| Jahr: | 17 November 2023 |
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| Umfang: | 19 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 08.10.2024 |
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| Titel Quelle: | Enthalten in: Journal of translational medicine |
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| Ort Quelle: | London : BioMed Central, 2003 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 21(2023), 1, Seite 1-19 |
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| ISSN Quelle: | 1479-5876 |
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| Abstract: | Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic extract derived from Zanthoxylum bungeanum Maxim, has anti-inflammatory and antioxidant biological activity, however, its function and mechanism in DIC remain unclear. We established DOX-induced cardiotoxicity models both in vitro and in vivo. Echocardiography and histological analyses were used to determine the severity of cardiac injury in mice. The myocardial damage markers cTnT, CK-MB, ANP, BNP, and ferroptosis associated indicators Fe2+, MDA, and GPX4 were measured using ELISA, RT-qPCR, and western blot assays. The morphology of mitochondria was investigated with a transmission electron microscope. The levels of mitochondrial membrane potential, mitochondrial ROS, and lipid ROS were detected using JC-1, MitoSOX™, and C11-BODIPY 581/591 probes. Our findings demonstrate that WGX50 protects DOX-induced cardiotoxicity via restraining mitochondrial ROS and ferroptosis. In vivo, WGX50 effectively relieves doxorubicin-induced cardiac dysfunction, cardiac injury, fibrosis, mitochondrial damage, and redox imbalance. In vitro, WGX50 preserves mitochondrial function by reducing the level of mitochondrial membrane potential and increasing mitochondrial ATP production. Furthermore, WGX50 reduces iron accumulation and mitochondrial ROS, increases GPX4 expression, and regulates lipid metabolism to inhibit DOX-induced ferroptosis. Taken together, WGX50 protects DOX-induced cardiotoxicity via mitochondrial ROS and the ferroptosis pathway, which provides novel insights for WGX50 as a promising drug candidate for cardioprotection. |
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| DOI: | doi:10.1186/s12967-023-04715-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s12967-023-04715-1 |
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| | kostenfrei: Volltext: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04715-1 |
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| | DOI: https://doi.org/10.1186/s12967-023-04715-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1905057024 |
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| Verknüpfungen: | → Zeitschrift |
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WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis / Tai, Panpan [VerfasserIn]; 17 November 2023 (Online-Ressource)
