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| Verfasst von: | Wurschi, Georg [VerfasserIn]  |
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| | Rühle, Alexander [VerfasserIn] |
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| | Domschikowski, Justus [VerfasserIn] |
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| | Trommer, Maike [VerfasserIn] |
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| | Ferdinandus, Simone [VerfasserIn] |
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| | Becker, Jan-Niklas [VerfasserIn] |
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| | Böke, Simon [VerfasserIn] |
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| | Sonnhoff, Mathias [VerfasserIn] |
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| | Fink, Christoph Andreas [VerfasserIn] |
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| | Käsmann, Lukas [VerfasserIn] |
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| | Schneider, Melanie [VerfasserIn] |
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| | Bockelmann, Elodie [VerfasserIn] |
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| | Krug, David [VerfasserIn] |
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| | Nicolay, Nils [VerfasserIn] |
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| | Fabian, Alexander [VerfasserIn] |
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| | Pietschmann, Klaus [VerfasserIn] |
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| Titel: | Patient-relevant costs for organ preservation versus radical resection in locally advanced rectal cancer |
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| Verf.angabe: | Georg W. Wurschi, Alexander Rühle, Justus Domschikowski, Maike Trommer, Simone Ferdinandus, Jan-Niklas Becker, Simon Boeke, Mathias Sonnhoff, Christoph A. Fink, Lukas Käsmann, Melanie Schneider, Elodie Bockelmann, David Krug, Nils H. Nicolay, Alexander Fabiana and Klaus Pietschmann |
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| E-Jahr: | 2024 |
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| Jahr: | 26 March 2024 |
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| Umfang: | 18 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 08.10.2024 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 16(2024), 7, Artikel-ID 1281, Seite 1-18 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Total neoadjuvant therapy (TNT) is an evolving treatment schedule for locally advanced rectal cancer (LARC), allowing for organ preservation in a relevant number of patients in the case of complete response. Patients who undergo this so-called “watch and wait” approach are likely to benefit regarding their quality of life (QoL), especially if definitive ostomy could be avoided. In this work, we performed the first cost-effectiveness analysis from the patient perspective to compare costs for TNT with radical resection after neoadjuvant chemoradiation (CRT) in the German health care system. Individual costs for patients insured with a statutory health insurance were calculated with a Markov microsimulation. A subgroup analysis from the prospective “FinTox” trial was used to calibrate the model’s parameters. We found that TNT was less expensive (−1540 EUR) and simultaneously resulted in a better QoL (+0.64 QALYs) during treatment and 5-year follow-up. The average cost for patients under TNT was 4711 EUR per year, which was equivalent to 3.2% of the net household income. CRT followed by resection resulted in higher overall costs for ostomy care, medication and greater loss of earnings. Overall, TNT appeared to be more efficacious and cost-effective from a patient’s point of view in the German health care system. |
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| DOI: | doi:10.3390/cancers16071281 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cancers16071281 |
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| | Volltext: https://www.mdpi.com/2072-6694/16/7/1281 |
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| | DOI: https://doi.org/10.3390/cancers16071281 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cost-effectiveness |
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| | financial toxicity |
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| | rectal cancer |
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| | total neoadjuvant therapy |
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| | watch and wait |
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| K10plus-PPN: | 1905058462 |
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| Verknüpfungen: | → Zeitschrift |
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Patient-relevant costs for organ preservation versus radical resection in locally advanced rectal cancer / Wurschi, Georg [VerfasserIn]; 26 March 2024 (Online-Ressource)
