Status: Bibliographieeintrag
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| Verfasst von: | Wang, Dan [VerfasserIn]  |
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| | Treede, Rolf-Detlef [VerfasserIn] |
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| | Koehr, Georg [VerfasserIn] |
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| Titel: | Electrophysiological evidence that TRPM3 is a candidate in latent spinal sensitization of chronic low back pain |
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| Verf.angabe: | Dan Wang, Rolf-Detlef Treede, Georg Köhr |
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| E-Jahr: | 2023 |
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| Jahr: | 1 November 2023 |
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| Umfang: | 8 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 5. Oktober 2023, Artikelversion: 10. Oktober 2023 ; Gesehen am 08.10.2024 |
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| Titel Quelle: | Enthalten in: Neuroscience letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 816(2023), Artikel-ID 137509, Seite 1-8 |
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| ISSN Quelle: | 1872-7972 |
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| Abstract: | Latent spinal sensitization is one key mechanism developing at the early stage of chronic low back pain (LBP). TRPM3-mediated calcium transients of dorsal root ganglia (DRG) neurons are considered critical presynaptic signals involved in this latent sensitization. However, postsynaptic consequences in input laminae of the spinal cord have not been addressed so far. Here, by electrophysiological recordings in acute spinal cord slices from adult rats, we show that perfusion of the TRPM3 agonist pregnenolone sulfate (PregS) induced a significant increase in the frequency but not amplitude of spontaneous postsynaptic currents in lamina I and II neurons. This frequency increase started slowly during PregS perfusion but was reversible following washout. This result is consistent with a presynaptic action of the neurosteroid PregS, indicating the presynaptic expression of functional TRPM3 in the superficial dorsal horn of adult rats. Thus, PregS-induced TRPM3 activation enhances spinal synaptic strength, implying a mediating role of TRPM3 between neuroendocrine and nociceptive signaling, which might as well exist in chronic LBP primed by chronic stress that promotes the biosynthesis of PregS. |
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| DOI: | doi:10.1016/j.neulet.2023.137509 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neulet.2023.137509 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0304394023004688 |
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| | DOI: https://doi.org/10.1016/j.neulet.2023.137509 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Chronic stress |
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| | Dorsal root ganglia neuron |
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| | Neurosteroids |
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| | Pregnenolone sulfate |
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| | Spontaneous postsynaptic current |
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| | TRPM3 |
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| K10plus-PPN: | 1905059957 |
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| Verknüpfungen: | → Zeitschrift |
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Electrophysiological evidence that TRPM3 is a candidate in latent spinal sensitization of chronic low back pain / Wang, Dan [VerfasserIn]; 1 November 2023 (Online-Ressource)
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