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| Verfasst von: | Ferdinandus, Justin [VerfasserIn]  |
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| | Müller, H. [VerfasserIn] |
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| | Damaschin, C. [VerfasserIn] |
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| | Jacob, A. S. [VerfasserIn] |
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| | Meißner, Julia [VerfasserIn] |
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| | Krasniqi, F. [VerfasserIn] |
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| | Mey, U. [VerfasserIn] |
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| | Schöndube, D. [VerfasserIn] |
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| | Thiemer, J. [VerfasserIn] |
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| | Mathas, S. [VerfasserIn] |
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| | Zijlstra, J. [VerfasserIn] |
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| | Greil, R. [VerfasserIn] |
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| | Feuring-Buske, M. [VerfasserIn] |
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| | Markova, J. [VerfasserIn] |
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| | Rüffer, J. U. [VerfasserIn] |
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| | Kobe, C. [VerfasserIn] |
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| | Eich, H. -T. [VerfasserIn] |
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| | Baues, C. [VerfasserIn] |
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| | Fuchs, M. [VerfasserIn] |
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| | Borchmann, P. [VerfasserIn] |
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| | Behringer, K. [VerfasserIn] |
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| Titel: | Impact of individualized treatment on recovery from fatigue and return to work in survivors of advanced-stage Hodgkin’s lymphoma |
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| Titelzusatz: | results from the randomized international GHSG HD18 trial |
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| Verf.angabe: | J. Ferdinandus, H. Müller, C. Damaschin, A.S. Jacob, J. Meissner, F. Krasniqi, U. Mey, D. Schöndube, J. Thiemer, S. Mathas, J. Zijlstra, R. Greil, M. Feuring-Buske, J. Markova, J.U. Rüffer, C. Kobe, H.-T. Eich, C. Baues, M. Fuchs, P. Borchmann & K. Behringer |
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| E-Jahr: | 2024 |
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| Jahr: | March 2024 |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar 5 December 2023, Version des Artikels 21 February 2024 ; Note: This study was previously presented at ICML 2023 meeting in Lugano, CH ; Gesehen am 09.10.2024 |
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| Titel Quelle: | Enthalten in: Annals of oncology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1990 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 35(2024), 3 vom: März, Seite 276-284 |
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| ISSN Quelle: | 1569-8041 |
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| Abstract: | Background - Persisting cancer-related fatigue impairs health-related quality of life (HRQoL) and social reintegration in patients with Hodgkin’s lymphoma (HL). The GHSG HD18 trial established treatment de-escalation for advanced-stage HL guided by positron emission tomography after two cycles (PET-2) as new standard. Here, we investigate the impact of treatment de-escalation on long-term HRQoL, time to recovery from fatigue (TTR-F), and time to return to work (TTR-W). - Patients and methods - Patients received European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and life situation questionnaires at baseline, interim, end of treatment, and yearly follow-up. TTR-F was defined as time from the end of chemotherapy until the first fatigue score <30. TTR-W was analyzed in previously working or studying patients and measured from the end of treatment until the first documented work or education. We compared duration of treatment on TTR-F and TTR-W using Cox proportional hazards regression adjusted for confounding variables. - Results - HRQoL questionnaires at baseline were available in 1632 (83.9%) of all randomized patients. Overall, higher baseline fatigue and age were significantly associated with longer TTR-F and TTR-W and male sex with shorter TTR-W. Treatment reduction from eight to four chemotherapy cycles led to a significantly shorter TTR-F [hazard ratio (HR) 1.41, P = 0.008] and descriptively shorter TTR-W (HR 1.24, P = 0.084) in PET-2-negative patients. Reduction from six to four cycles led to non-significant but plausible intermediate accelerations. The addition of rituximab caused significantly slower TTR-F (HR 0.70, P = 0.0163) and TTR-W (HR 0.64, P = 0.0017) in PET-2-positive patients. HRQoL at baseline and age were the main determinants of 2-year HRQoL. - Conclusions - Individualized first-line treatment in patients with advanced-stage HL considerably shortens TTR-F and TTR-W in PET-2-negative patients. Our results support the use of response-adapted shortened treatment duration for patients with HL. |
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| DOI: | doi:10.1016/j.annonc.2023.11.014 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.annonc.2023.11.014 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0923753423051025 |
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| | DOI: https://doi.org/10.1016/j.annonc.2023.11.014 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | fatigue |
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| | Hodgkin’s lymphoma |
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| | quality of life |
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| | recovery |
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| | return to work |
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| | survivorship |
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| K10plus-PPN: | 1905210531 |
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| Verknüpfungen: | → Zeitschrift |
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Impact of individualized treatment on recovery from fatigue and return to work in survivors of advanced-stage Hodgkin’s lymphoma / Ferdinandus, Justin [VerfasserIn]; March 2024 (Online-Ressource)
