Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Hundeshagen, Gabriel [VerfasserIn]   i
 Blears, Elisabeth [VerfasserIn]   i
 Mertin, Viktoria [VerfasserIn]   i
 Day, Andrew G [VerfasserIn]   i
 Palackic, Alen [VerfasserIn]   i
 Tapking, Christian [VerfasserIn]   i
 Haug, Valentin [VerfasserIn]   i
 Kneser, Ulrich [VerfasserIn]   i
 Bliesener, Björn [VerfasserIn]   i
 Panayi, Adriana C. [VerfasserIn]   i
 Aballay, Ariel [VerfasserIn]   i
 Depret, Francois [VerfasserIn]   i
 Stoppe, Christian [VerfasserIn]   i
 Heyland, Daren K [VerfasserIn]   i
Titel:Administration and effects of beta blockers and oxandrolone in severely burned adults
Titelzusatz:a post hoc analysis of the RE-ENERGIZE trial
Verf.angabe:Gabriel Hundeshagen, Elisabeth Blears, Viktoria Mertin, Andrew G Day, Alen Palackic, Christian Tapking, Valentin Haug, Ulrich Kneser, Björn Bliesener, Adriana C Panayi, Ariel Aballay, Francois Depret, Christian Stoppe and Daren K Heyland
Jahr:2024
Umfang:10 S.
Illustrationen:Diagramme
Fussnoten:Online veröffentlicht: 21. April 2024 ; Gesehen am 10.10.2024
Titel Quelle:Enthalten in: Burns & trauma
Ort Quelle:Mumbai : Medknow Publ., 2013
Jahr Quelle:2024
Band/Heft Quelle:12(2024), Artikel-ID tkad063, Seite 1-10
ISSN Quelle:2321-3876
Abstract:Prospective randomized trials in severely burned children have shown the positive effects of oxandrolone (OX), beta blockers (BB) and a combination of the two (BBOX) on hypermetabolism, catabolism and hyperinflammation short- and long-term post-burn. Although data on severely burned adults are lacking in comparison, BB, OX and BBOX appear to be commonly employed in this patient population. In this study, we perform a secondary analysis of an international prospective randomized trial dataset to provide descriptive evidence regarding the current utilization patterns and potential treatment effects of OX, BB and BBOX.The RE-ENERGIZE (RandomizEd Trial of ENtERal Glutamine to minimIZE Thermal Injury, NCT00985205) trial included 1200 adult patients with severe burns. We stratified patients according to their receipt of OX, BB, BBOX or none of these drugs (None) during acute hospitalization. Descriptive statistics describe the details of drug therapy and unadjusted analyses identify predisposing factors for drug use per group. Association between OX, BB and BBOX and clinical outcomes such as time to discharge alive and 6-month mortality were modeled using adjusted multivariable Cox regressions.More than half of all patients in the trial received either OX (n = 138), BB (n = 293) or BBOX (n = 282), as opposed to None (n = 487, 40.6%). Per study site and geographical region, use of OX, BB and BBOX was highly variable. Predisposing factors for the use of OX, BB and BBOX included larger total body surface area (TBSA) burned, higher acute physiology and chronic health evaluation (APACHE) II scores on admission and younger patient age. After adjustment for multiple covariates, the use of OX was associated with a longer time to discharge alive [hazard ratio (HR) 0.62, confidence interval (CI) (0.47-0.82) per 100% increase, p = 0.001]. A higher proportion of days on BB was associated with lower in-hospital-mortality (HR: 0.5, CI 0.28-0.87, p = 0.015) and 6-month mortality (HR: 0.44, CI 0.24-0.82, p = 0.01).The use of OX, BB and BBOX is common within the adult burn patient population, with its use varying considerably across sites worldwide. Our findings found mixed associations between outcomes and the use of BB and OX in adult burn patients, with lower acute and 6-month-mortality with BB and longer times to discharge with OX. Further research into these pharmacological modulators of the pathophysiological response to severe burn injury is indicated.
DOI:doi:10.1093/burnst/tkad063
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1093/burnst/tkad063
 DOI: https://doi.org/10.1093/burnst/tkad063
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1905323247
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69261161   QR-Code
zum Seitenanfang