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Verfasst von:Roth, Sebastian [VerfasserIn]   i
 M’Pembele, René [VerfasserIn]   i
 Matute, Purificación [VerfasserIn]   i
 Kotfis, Katarzyna [VerfasserIn]   i
 Larmann, Jan [VerfasserIn]   i
 Lurati Buse, Giovanna [VerfasserIn]   i
Titel:Cardiovascular-kidney-metabolic syndrome
Titelzusatz:association with adverse events after major noncardiac surgery
Verf.angabe:Sebastian Roth, MD, René M’Pembele, MD, Purificación Matute, MD, PhD, Katarzyna Kotfis, MD, PhD,Jan Larmann, MD, PhD, and Giovanna Lurati Buse, MD, MSc
E-Jahr:2024
Jahr:Septemberg 2024
Umfang:3 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 10.10.2024
Titel Quelle:Enthalten in: Anesthesia & analgesia
Ort Quelle:Baltimore, Md. : Williams & Wilkins, 1957
Jahr Quelle:2024
Band/Heft Quelle:139(2024), 3 vom: Sept., Seite 679-681
ISSN Quelle:1526-7598
Abstract:BACKGROUND: - The American Heart Association (AHA) recently defined the cardiovascular-kidney-metabolic syndrome (CKM) as a new entity to address the complex interactions between heart, kidneys, and metabolism. The aim of this study was to assess the outcome impact of CKM syndrome in patients undergoing noncardiac surgery. - METHODS: - This is a secondary analysis of a prospective international cohort study including patients aged ≥45 years with increased cardiovascular risk undergoing noncardiac surgery. Main exposure was CKM syndrome according to the AHA definition. The primary end point was a composite of major adverse cardiovascular events (MACE) 30 days after surgery. Secondary end points included all-cause mortality and non-MACE complications (Clavien-Dindo class ≥3). - RESULTS: - This analysis included 14,634 patients (60.8% male, mean age = 72±8 years). MACE occurred in 308 patients (2.1%), and 335 patients (2.3%) died. MACE incidence by CKM stage was as follows: CKM 0: 5/367 = 1.4% (95% confidence interval [CI], 0.4%-3.2%); CKM 1: 3/367 = 0.8% (95% CI, 0.2%-2.4%); CKM 2: 102/7440 = 1.4% (95% CI, 1.1%-1.7%); CKM 3: 27/953 = 2.8% (95% CI, 1.9%-4.1%); CKM 4a: 164/5357 = 3.1% (95% CI, 2.6%-3.6%); CKM 4b: 7/150 = 4.7% (95% CI, 1.9%-9.4%). In multivariate logistic regression, CKM stage ≥3 was independently associated with MACE, mortality, and non-MACE complications, respectively (MACE: OR 2.26 [95% CI, 1.78-2.87]; mortality: OR 1.42 [95% CI: 1.13 -1.78]; non-MACE complications: OR 1.11 [95% CI: 1.03-1.20]). - CONCLUSION: - The newly defined CKM syndrome is associated with increased morbidity and mortality after non-cardiac surgery. Thus, cardiovascular, renal, and metabolic disorders should be regarded in mutual context in this setting.
DOI:doi:10.1213/ANE.0000000000006975
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1213/ANE.0000000000006975
 Volltext: https://journals.lww.com/anesthesia-analgesia/fulltext/2024/09000/cardiovascular_kidney_metabolic_syndrome_.27.aspx
 DOI: https://doi.org/10.1213/ANE.0000000000006975
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1905347111
Verknüpfungen:→ Zeitschrift

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