| |  Online-Ressource |
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| Verfasst von: | Song, Xue Mei [VerfasserIn]  |
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| | Liu, Dong-Yu [VerfasserIn] |
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| | Hirjak, Dusan [VerfasserIn] |
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| | Hu, Xi-Wen [VerfasserIn] |
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| | Han, Jin-Fang [VerfasserIn] |
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| | Roe, Anna Wang [VerfasserIn] |
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| | Yao, De-Zhong [VerfasserIn] |
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| | Tan, Zhong-Lin [VerfasserIn] |
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| | Northoff, Georg [VerfasserIn] |
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| Titel: | Motor versus psychomotor? |
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| Titelzusatz: | deciphering the neural source of psychomotor retardation in depression |
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| Verf.angabe: | Xue Mei Song, Dong-Yu Liu, Dusan Hirjak, Xi-Wen Hu, Jin-Fang Han, Anna Wang Roe, De-Zhong Yao, Zhong-Lin Tan, and Georg Northoff |
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| Jahr: | 2024 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 11.10.2024 |
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| Titel Quelle: | Enthalten in: Advanced science |
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| Ort Quelle: | Weinheim : Wiley-VCH, 2014 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | (2024), Artikel-ID 2403063, Seite 1-13 |
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| ISSN Quelle: | 2198-3844 |
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| Abstract: | Major depressive disorder (MDD) is characterized by psychomotor retardation whose underlying neural source remains unclear. Psychomotor retardation may either be related to a motor source like the motor cortex or, alternatively, to a psychomotor source with neural changes outside motor regions, like input regions such as visual cortex. These two alternative hypotheses in main (n = 41) and replication (n = 18) MDD samples using 7 Tesla MRI are investigated. Analyzing both global and local connectivity in primary motor cortex (BA4), motor network and middle temporal visual cortex complex (MT+), the main findings in MDD are: 1) Reduced local and global synchronization and increased local-to-global output in motor regions, which do not correlate with psychomotor retardation, though. 2) Reduced local-to-local BA4 - MT+ functional connectivity (FC) which correlates with psychomotor retardation. 3) Reduced global synchronization and increased local-to-global output in MT+ which relate to psychomotor retardation. 4) Reduced variability in the psychophysical measures of MT+ based motion perception which relates to psychomotor retardation. Together, it is shown that visual cortex MT+ and its relation to motor cortex play a key role in mediating psychomotor retardation. This supports psychomotor over motor hypothesis about the neural source of psychomotor retardation in MDD. |
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| DOI: | doi:10.1002/advs.202403063 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/advs.202403063 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202403063 |
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| | DOI: https://doi.org/10.1002/advs.202403063 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | major depressive disorder |
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| | middle temporal visual complex |
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| | motion perception |
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| | primary motor cortex |
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| | psychomotor retardation |
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| K10plus-PPN: | 1905477937 |
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| Verknüpfungen: | → Zeitschrift |
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Motor versus psychomotor? / Song, Xue Mei [VerfasserIn]; 2024 (Online-Ressource)
