The associations of serum vitamin D status and vitamin D supplements use with all-cause dementia, Alzheimer’s disease, and vascular dementia

• Verfasst von: Chen, Li-Ju [VerfasserIn]
• Verfasst von: Sha, Sha [VerfasserIn]
• Verfasst von: Stocker, Hannah [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Schöttker, Ben [VerfasserIn]
• Titel: The associations of serum vitamin D status and vitamin D supplements use with all-cause dementia, Alzheimer’s disease, and vascular dementia
• Titelzusatz: a UK Biobank based prospective cohort study
• Verf.angabe: Li-Ju Chen, Sha Sha, Hannah Stocker, Hermann Brenner, Ben Schöttker
• E-Jahr: 2024
• Jahr: 29 January 2024
• Umfang: 13 S.
• Fussnoten: Gesehen am 11.10.2024
• Titel Quelle: Enthalten in: The American journal of clinical nutrition
• Ort Quelle: Amsterdam : Elsevier, 1952
• Jahr Quelle: 2024
• Band/Heft Quelle: 119(2024), 4, Seite 1052-1064
• ISSN Quelle: 1938-3207
• ISSN Quelle: 1938-3215
• DOI: doi:10.1016/j.ajcnut.2024.01.020
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Alzheimer’s disease
• Sach-SW: cohort study
• Sach-SW: dementia
• Sach-SW: vascular dementia
• Sach-SW: vitamin D
• K10plus-PPN: 1905516606

Abstract

Background - Prior studies on vitamin D and dementia outcomes yielded mixed results and had several important limitations. - Objectives - We aimed to assess the associations of both serum vitamin D status and supplementation with all-cause dementia, Alzheimer’s disease (AD), and vascular dementia (VD) incidence. - Methods - With a prospective cohort study design, we comprehensively assessed the associations of vitamin D and multivitamin supplementation, as well as vitamin D deficiency {25-hydroxyvitamin D [25(OH)D] <30 nmol/L}, and insufficiency [25(OH)D 30 to <50 nmol/L], with the 14-year incidence of all-cause dementia, AD, and VD in 269,229 participants, aged 55 to 69, from the UK Biobank. - Results - Although 5.0% reported regular vitamin D use and 19.8% reported multivitamin use, the majority of participants exhibited either vitamin D deficiency (18.3%) or insufficiency (34.0%). However, vitamin D deficiency was less prevalent among users of vitamin D (6.9%) or multivitamin preparations (9.5%) than among nonusers (21.5%). Adjusted Cox regression models demonstrated 19% to 25% increased risk of all 3 dementia outcomes for those with vitamin D deficiency [hazard ratio (HR) 95% confidence interval (CI)]: 1.25 (1.16, 1.34) for all-cause dementia; 1.19 (1.07-1.31) for AD; 1.24 (1.08-1.43) for VD] and 10% to 15% increased risk of those with vitamin D insufficiency [HR (95% CI): 1.11 (1.05, 1.18) for all-cause dementia; 1.10 (1.02-1.19) for AD; 1.15 (1.03-1.29) for VD]. Regular users of vitamin D and multivitamins had 17% and 14% lower risk of AD [HR (95% CI): 0.83 (0.71, 0.98)] and VD [HR (95% CI): 0.86 (0.75, 0.98)] incidence, respectively. - Conclusions - Although our findings indicate the potential benefits of vitamin D supplementation for dementia prevention, randomized controlled trials are essential for definitive evidence.