Intraocular amphiregulin and axial elongation in non-human adolescent primates

• Verfasst von: Dong, Li [VerfasserIn]
• Verfasst von: Wu, Hao Tian [VerfasserIn]
• Verfasst von: Zhang, Rui Heng [VerfasserIn]
• Verfasst von: Niu, Ling Han [VerfasserIn]
• Verfasst von: Wang, Ya Xing [VerfasserIn]
• Verfasst von: Wei, Wen Bin [VerfasserIn]
• Verfasst von: Panda-Jonas, Songhomitra [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Titel: Intraocular amphiregulin and axial elongation in non-human adolescent primates
• Verf.angabe: Li Dong, Hao Tian Wu, Rui Heng Zhang, Ling Han Niu, Ya Xing Wang, Wen Bin Wei, Songhomitra Panda-Jonas, Jost B. Jonas
• E-Jahr: 2024
• Jahr: October 2024
• Umfang: 7 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 22. August 2024, Artikelversion: 26. August 2024 ; Gesehen am 14.10.2024
• Titel Quelle: Enthalten in: Experimental eye research
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1962
• Jahr Quelle: 2024
• Band/Heft Quelle: 247(2024) vom: Okt., Artikel-ID 110059, Seite 1-7
• ISSN Quelle: 1096-0007
• DOI: doi:10.1016/j.exer.2024.110059
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Amphiregulin
• Sach-SW: Axial elongation
• Sach-SW: Epidermal growth factor
• Sach-SW: High myopia
• Sach-SW: Hyperopia
• Sach-SW: Myopia
• Sach-SW: Myopic maculopathy
• K10plus-PPN: 1905605757

Abstract

The purpose of the experimental interventional study was to examine the influence of intraocularly applied amphiregulin, a member of the epidermal growth factor (EGF) family, on axial length in young non-human primates. It included three non-human primates (Macaca mulatta), aged 4-6 years. The left eyes received three intravitreal injections of amphiregulin (400ng/50 μl) in intervals of 4 weeks, while the right eyes received three intravitreal injections of phosphate buffered solution (50 μl) at the same time points. Ocular biometry was performed in weekly intervals. At baseline, the left eyes (study eyes) were shorter than the right (control) eyes (20.69 ± 0.21 mm versus 20.79 ± 0.24 mm; P < 0.001), with an inter-eye axial length (AL) difference (left minus right eye) of −0.10 ± 0.23 mm. Inter-eye AL difference increased (P < 0.001) to 0.15 ± 0.18 mm at study end, at 12 weeks after baseline. Axial elongation during the study was higher (P < 0.001) in the left eyes (20.69 ± 0.21 mm to 21.05 ± 0.29 mm or 0.36 ± 0.30 mm) than in the right eyes (20.79 ± 0.24 mm to 20.90 ± 0.31 mm or 0.11 ± 0.17 mm). In a parallel manner, inter-eye difference in vitreous cavity depth combined with lens thickness (left eye minus right eye) increased from −0.04 ± 0.17 mm at baseline to −0.02 ± 0.21 mm (P = 0.02), 0.04 ± 0.10 mm (P = 0.002), and to 0.42 ± 0.67 mm (P < 0.001) at 5, 6, and 12 weeks after baseline, respectively. The results suggest that intravitreally applied amphiregulin as EGF family member led to an increase in axial length in adolescent non-human primates. It supports the hypothesis of amphiregulin as EGF family member being involved in the process of axial elongation.