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| Verfasst von: | Teixeira, Ana Rafaela [VerfasserIn]  |
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| | Bittar, Cintia [VerfasserIn] |
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| | Silva Santos, Gabriela S. [VerfasserIn] |
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| | Oliveira, Thiago Y. [VerfasserIn] |
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| | Huang, Amy S. [VerfasserIn] |
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| | Linden, Noemi [VerfasserIn] |
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| | Ferreira, Isabella A.T.M. [VerfasserIn] |
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| | Murdza, Tetyana [VerfasserIn] |
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| | Mücksch, Frauke [VerfasserIn] |
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| | Jones, R. Brad [VerfasserIn] |
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| | Caskey, Marina [VerfasserIn] |
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| | Jankovic, Mila [VerfasserIn] |
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| | Nussenzweig, Michel C. [VerfasserIn] |
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| Titel: | Transcription of HIV-1 at sites of intact latent provirus integration |
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| Verf.angabe: | Ana Rafaela Teixeira, Cintia Bittar, Gabriela S. Silva Santos, Thiago Y. Oliveira, Amy S. Huang, Noemi Linden, Isabella A.T.M. Ferreira, Tetyana Murdza, Frauke Muecksch, R. Brad Jones, Marina Caskey, Mila Jankovic, and Michel C. Nussenzweig |
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| E-Jahr: | 2024 |
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| Jahr: | August 14 2024 |
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| Umfang: | 18 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 15.10.2024 |
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| Titel Quelle: | Enthalten in: Journal of experimental medicine |
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| Ort Quelle: | New York, NY : Rockefeller Univ. Press, 1896 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 221(2024), 9, Artikel-ID e20240391, Seite 1-18 |
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| ISSN Quelle: | 1540-9538 |
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| Abstract: | HIV-1 antiretroviral therapy is highly effective but fails to eliminate a reservoir of latent proviruses, leading to a requirement for life-long treatment. How the site of integration of authentic intact latent proviruses might impact their own or neighboring gene expression or reservoir dynamics is poorly understood. Here, we report on proviral and neighboring gene transcription at sites of intact latent HIV-1 integration in cultured T cells obtained directly from people living with HIV, as well as engineered primary T cells and cell lines. Proviral gene expression was correlated to the level of endogenous gene expression under resting but not activated conditions. Notably, latent proviral promoters were 100-10,000× less active than in productively infected cells and had little or no measurable impact on neighboring gene expression under resting or activated conditions. Thus, the site of integration has a dominant effect on the transcriptional activity of intact HIV-1 proviruses in the latent reservoir, thereby influencing cytopathic effects and proviral immune evasion. |
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| DOI: | doi:10.1084/jem.20240391 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1084/jem.20240391 |
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| | DOI: https://doi.org/10.1084/jem.20240391 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1905689527 |
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| Verknüpfungen: | → Zeitschrift |
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Transcription of HIV-1 at sites of intact latent provirus integration / Teixeira, Ana Rafaela [VerfasserIn]; August 14 2024 (Online-Ressource)
