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Verfasst von:Weyrich, Michael [VerfasserIn]   i
 Cremer, Sebastian [VerfasserIn]   i
 Gerster, Martin [VerfasserIn]   i
 Sarakpi, Tamim [VerfasserIn]   i
 Rasper, Tina [VerfasserIn]   i
 Zewinger, Stephen [VerfasserIn]   i
 Patyna, Sammy R. [VerfasserIn]   i
 Leistner, David M. [VerfasserIn]   i
 Heine, Gunnar H. [VerfasserIn]   i
 Wanner, Christoph [VerfasserIn]   i
 März, Winfried [VerfasserIn]   i
 Fliser, Danilo [VerfasserIn]   i
 Dimmeler, Stefanie [VerfasserIn]   i
 Zeiher, Andreas M. [VerfasserIn]   i
 Speer, Thimoteus [VerfasserIn]   i
Titel:Loss of Y chromosome and cardiovascular events in chronic kidney disease
Verf.angabe:Michael Weyrich, MD; Sebastian Cremer, MD; Martin Gerster, MD; Tamim Sarakpi, MD; Tina Rasper, MS; Stephen Zewinger , MD; Sammy R. Patyna , MD; David M. Leistner , MD; Gunnar H. Heine, MD; Christoph Wanner , MD; Winfried März , MD; Danilo Fliser, MD; Stefanie Dimmeler , PhD; Andreas M. Zeiher , MD; Thimoteus Speer , MD, PhD
E-Jahr:2024
Jahr:Sep 2024
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 15. Juli 2024 ; Gesehen am 21.10.2024
Titel Quelle:Enthalten in: Circulation
Ort Quelle:Philadelphia, Pa. : Lippincott, Williams & Wilkins, 1950
Jahr Quelle:2024
Band/Heft Quelle:150(2024), 10, Seite 746-757
ISSN Quelle:1524-4539
Abstract:BACKGROUND: - Chronic kidney disease represents one of the strongest risk factors for cardiovascular diseases, and particularly for heart failure. Despite improved pharmaceutical treatments, mortality remains high. Recently, experimental studies demonstrated that mosaic loss of Y chromosome (LOY) associates with cardiac fibrosis in male mice. Since diffuse cardiac fibrosis is the common denominator for progression of all forms of heart failure, we determined the association of LOY on mortality and cardiovascular disease outcomes in patients with chronic kidney disease. - METHODS: - LOY was quantified in men with stable chronic kidney disease (CARE for HOMe study, n=279) and dialysis patients (4D study, n=544). The association between LOY and mortality, combined cardiovascular and heart failure-specific end points, and echocardiographic measures was assessed. - RESULTS: - In CARE for HOMe, the frequency of LOY increased with age. LOY >17% was associated with increased mortality (heart rate, 2.58 [95% CI, 1.33-5.03]) and risk for cardiac decompensation or death (heart rate, 2.30 [95% CI, 1.23-4.27]). Patients with LOY >17% showed a significant decline of ejection fraction and an increase of E/E’ within 5 years. Consistently, in the 4D study, LOY >17% was significantly associated with increased mortality (heart rate, 2.76 [95% CI, 1.83-4.16]), higher risk of death due to heart failure and sudden cardiac death (heart rate, 4.11 [95% CI, 2.09-8.08]), but not atherosclerotic events. Patients with LOY >17% showed significantly higher plasma levels of soluble interleukin 1 receptor-like 1, a biomarker for myocardial fibrosis. Mechanistically, intermediate monocytes from patients with LOY >17% showed significantly higher C-C chemokine receptor type 2 expression and higher plasma levels of the C-C chemokine receptor type 2 chemokine (C-C motif) ligand 2, which may have contributed to increased heart failure events. - CONCLUSIONS: - LOY identifies male patients with chronic kidney disease at high risk for mortality and heart failure events.
DOI:doi:10.1161/CIRCULATIONAHA.124.069139
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1161/CIRCULATIONAHA.124.069139
 Volltext: https://www-ahajournals-org.ezproxy.medma.uni-heidelberg.de/doi/10.1161/CIRCULATIONAHA.124.069139
 DOI: https://doi.org/10.1161/CIRCULATIONAHA.124.069139
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:190632624X
Verknüpfungen:→ Zeitschrift

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