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Status: Bibliographieeintrag

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Verfasst von:Fels-Palesandro, Hannah [VerfasserIn]   i
 Heuer, Sophie [VerfasserIn]   i
 Boztepe, Berin [VerfasserIn]   i
 Streibel, Yannik [VerfasserIn]   i
 Ungermann, Johannes [VerfasserIn]   i
 Pan, Chenchen [VerfasserIn]   i
 Scheck, Jonas [VerfasserIn]   i
 Fischer, Manuel [VerfasserIn]   i
 Sturm, Volker Jörg Friedrich [VerfasserIn]   i
 Azorín, Daniel D. [VerfasserIn]   i
 Karimian-Jazi, Kianush [VerfasserIn]   i
 Annio, Giacomo [VerfasserIn]   i
 Abdollahi, Amir [VerfasserIn]   i
 Weidenfeld, Ina [VerfasserIn]   i
 Wick, Wolfgang [VerfasserIn]   i
 Venkataramani, Varun [VerfasserIn]   i
 Heiland, Sabine [VerfasserIn]   i
 Winkler, Frank [VerfasserIn]   i
 Bendszus, Martin [VerfasserIn]   i
 Sinkus, Ralph [VerfasserIn]   i
 Breckwoldt, Michael O. [VerfasserIn]   i
 Schregel, Katharina [VerfasserIn]   i
Titel:Assessment of tumor cell invasion and radiotherapy response in experimental glioma by magnetic resonance elastography
Verf.angabe:Hannah Fels-Palesandro, MSc, Sophie Heuer, MD, Berin Boztepe, MSc, Yannik Streibel,Johannes Ungermann, BSc, Chenchen Pan, PhD, Jonas G. Scheck, Manuel Fischer, Volker J. Sturm, PhD, Daniel D. Azorín, PhD, Kianush Karimian-Jazi, MD, Giacomo Annio, PhD, Amir Abdollahi, MD, PhD, Ina Weidenfeld, PhD, Wolfgang Wick, MD, Varun Venkataramani, MD, PhD, Sabine Heiland, PhD, Frank Winkler, MD, Martin Bendszus, MD, Ralph Sinkus, PhD, Michael O. Breckwoldt, MD, PhD, and Katharina Schregel, MD
E-Jahr:2024
Jahr:23. August 2024
Umfang:16 S.
Illustrationen:Illustrationen
Fussnoten:Vorab veröffentlicht: 23. August 2024 ; Gesehen am 21.10.2024
Titel Quelle:Enthalten in: Journal of magnetic resonance imaging
Ort Quelle:New York, NY : Wiley-Liss, 1991
Jahr Quelle:2024
Band/Heft Quelle:(2024), Seite 1-16
ISSN Quelle:1522-2586
Abstract:Background Gliomas are highly invasive brain neoplasms. MRI is the most important tool to diagnose and monitor glioma but has shortcomings. In particular, the assessment of tumor cell invasion is insufficient. This is a clinical dilemma, as recurrence can arise from MRI-occult glioma cell invasion. Hypothesis Tumor cell invasion, tumor growth and radiotherapy alter the brain parenchymal microstructure and thus are assessable by diffusion tensor imaging (DTI) and MR elastography (MRE). Study Type Experimental, animal model. Animal Model Twenty-three male NMRI nude mice orthotopically implanted with S24 patient-derived glioma cells (experimental mice) and 9 NMRI nude mice stereotactically injected with 1 μL PBS (sham-injected mice). Field Strength/Sequence 2D and 3D T2-weighted rapid acquisition with refocused echoes (RARE), 2D echo planar imaging (EPI) DTI, 2D multi-slice multi-echo (MSME) T2 relaxometry, 3D MSME MRE at 900 Hz acquired at 9.4 T (675 mT/m gradient strength). Assessment Longitudinal 4-weekly imaging was performed for up to 4 months. Tumor volume was assessed in experimental mice (n = 10 treatment-control, n = 13 radiotherapy). The radiotherapy subgroup and 5 sham-injected mice underwent irradiation (3 × 6 Gy) 9 weeks post-implantation/sham injection. MRI-/MRE-parameters were assessed in the corpus callosum and tumor core/injection tract. Imaging data were correlated to light sheet microscopy (LSM) and histology. Statistical Tests Paired and unpaired t-tests, a P-value ≤0.05 was considered significant. Results From week 4 to 8, a significant callosal stiffening (4.44 ± 0.22 vs. 5.31 ± 0.29 kPa) was detected correlating with LSM-proven tumor cell invasion. This was occult to all other imaging metrics. Histologically proven tissue destruction in the tumor core led to an increased T2 relaxation time (41.65 ± 0.34 vs. 44.83 ± 0.66 msec) and ADC (610.2 ± 12.27 vs. 711.2 ± 13.42 × 10−6 mm2/s) and a softening (5.51 ± 0.30 vs. 4.24 ± 0.29 kPa) from week 8 to 12. Radiotherapy slowed tumor progression. Data Conclusion MRE is promising for the assessment of key glioma characteristics. Evidence Level NA Technical Efficacy Stage 2
DOI:doi:10.1002/jmri.29567
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/jmri.29567
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.29567
 DOI: https://doi.org/10.1002/jmri.29567
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:brain tumor
 glioma invasion
 MR elastography
 stiffness
 tissue biomechanics
 white matter
K10plus-PPN:1906331553
Verknüpfungen:→ Zeitschrift

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